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The aim of this work was to estimate risk of lung tumour occurrence after inhalation of actinide oxides from published studies and rat studies in progress. For the same delivered dose, the risk increases when homogeneity of irradiation increases, i.e., the number of particles deposited after inhalation increases (small particles and (or) low specific alpha activity). The dose-effect relationships reported appear linear up to a few gray, depending on the aerosol considered, and then the slope decreases. This slope, which corresponds with the risk, can vary over one order of magnitude depending on the aerosol used. An effective threshold at about 1 Gy was not observed for the most homogeneous dose distributions. A dosimetric and biological approach is proposed to provide a more realistic risk estimate.
机译:这项工作的目的是根据已发表的研究和进行中的大鼠研究估计吸入act系元素氧化物后发生肺肿瘤的风险。对于相同的给药剂量,当辐照的均匀性增加时,即吸入后沉积的颗粒数量增加(小颗粒和(或)低比活度),风险就会增加。所报告的剂量效应关系根据所考虑的气雾剂呈线性直至几灰色,然后斜率减小。该斜率与风险相对应,可根据所使用的气溶胶变化一个数量级。对于最均匀的剂量分布,未观察到约1 Gy的有效阈值。提出了一种剂量学和生物学方法来提供更现实的风险估计。

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