...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >The anti-apoptotic and anti-inflammatory properties of puerarin attenuate 3-nitropropionic-acid induced neurotoxicity in rats
【24h】

The anti-apoptotic and anti-inflammatory properties of puerarin attenuate 3-nitropropionic-acid induced neurotoxicity in rats

机译：葛根素的抗凋亡和抗炎特性减弱3-硝基丙酸诱导的大鼠神经毒性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Puerarin (Pur), an isoflavonoid extracted from the dried roots of Pueraria lobata, has been reported to be useful in the treatment of various diseases. This study was designed to evaluate the anti-apoptotic and anti-inflammatory activities of Pur against 3-nitropropionic acid (3-NP) induced neurotoxicity. For 5 consecutive days, male Wistar rats were given Pur (200 mg/kg body mass) 30 min before treatment with 20 mg/kg body mass of 3-NP. The striata, hippocampi, and cortices of the 3-NP treated group showed apoptotic damage, inflammation, and energy deficit as well as histopathological lesions. The 3-NP-induced alteration in apoptotic biomarkers (caspase-3 activity/level, cytosolic cytochrome c, Bax/Bcl-2 levels) were significantly ameliorated by Pur treatment. Moreover, Pur pretreatment blocked 3-NP-induced inflammatory biomarkers (NF-κB, TNF-α, and iNOS) and prevented the energy deficit (ATP reduction). Nissl staining further confirmed Pur's neuroprotective effect. These results indicate that Pur may be a useful preventive approach to various neurodegenerative diseases with underlying apoptosis and neuroinflammation.
机译：葛根素（Purerarin，Pur）是一种从葛根的干燥根中提取的异黄酮，据报道可用于治疗各种疾病。这项研究旨在评估Pur对3-硝基丙酸（3-NP）诱导的神经毒性的抗凋亡和抗炎活性。连续5天，在用20 mg / kg体重的3-NP治疗前30分钟，给雄性Wistar大鼠提供Pur（200 mg / kg体重）。 3-NP治疗组的纹状体，海马和皮质显示出细胞凋亡，炎症和能量缺乏以及组织病理学损害。 Pur治疗可显着改善3-NP诱导的凋亡生物标志物的改变（胱天蛋白酶3活性/水平，胞质细胞色素c，Bax / Bcl-2水平）。此外，Pur预处理可阻断3-NP诱导的炎症生物标记物（NF-κB，TNF-α和iNOS）并防止能量不足（ATP降低）。 Nissl染色进一步证实了Pur的神经保护作用。这些结果表明，Pur可能是一种有效的预防方法，可预防各种潜在的细胞凋亡和神经炎症性神经退行性疾病。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号