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首页> 外文期刊>Fish Physiology and Biochemistry >Effect of MK-801-induced impairment of inhibitory avoidance learning in zebrafish via inactivation of extracellular signal-regulated kinase (ERK) in telencephalon
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Effect of MK-801-induced impairment of inhibitory avoidance learning in zebrafish via inactivation of extracellular signal-regulated kinase (ERK) in telencephalon

机译：MK-801通过灭活端脑中细胞外信号调节激酶（ERK）导致的斑马鱼抑制回避学习障碍

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摘要

N-Methyl-d-aspartate (NMDA) receptors are implicated in a wide range of complex behavioral functions, including cognitive activity. Numerous studies have shown that using the repetitive administration of a noncompetitive NMDA receptor antagonist, MK-801, induces amnesia in rodents. In this study, the effect of a subchronic MK-801 treatment on the cognitive function of zebrafish was evaluated using a novel inhibitory avoidance task. First, we established a new system to investigate the inhibitory avoidance learning of zebrafish where they were trained to refrain from swimming from a shallow compartment to a deep compartment in order to avoid electric shock. Second, we found that blocking NMDA receptors by MK-801 could significantly attenuate the inhibitory avoidance behavior of the zebrafish and alter the telencephalic extracellular signal-regulated kinase (ERK) phosphorylation level 90 min after the inhibitory avoidance training. These results suggest that the formation of long-term emotional memory is possibly mediated by ERK activation in the telencephalon of zebrafish.
机译：N-甲基-d-天冬氨酸（NMDA）受体与多种复杂的行为功能有关，包括认知活动。大量研究表明，重复施用非竞争性NMDA受体拮抗剂MK-801可在啮齿动物中引起失忆症。在这项研究中，使用新型抑制回避任务评估了亚慢性MK-801治疗对斑马鱼认知功能的影响。首先，我们建立了一个新的系统来研究斑马鱼的抑制回避学习方法，在该系统中，他们被训练避免从浅室到深室游泳以避免触电。其次，我们发现，通过抑制回避训练90分钟后，MK-801阻断NMDA受体可以显着减弱斑马鱼的抑制回避行为，并改变端脑细胞外信号调节激酶（ERK）的磷酸化水平。这些结果表明，长期情绪记忆的形成可能是由斑马鱼端脑中的ERK激活介导的。

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