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Diet and Genomic Stability

机译：饮食和基因组稳定性

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Cancer results from a disordered and unstable genome - the degree of abnormality progresses as the process of oncogenesis proceeds. Such genomic instability appears to be subject to control by environmental factors as evidenced by the number of cancers that are either caused by specific environmental agents (lung, skin, cervix) or else regulated by a broader range of agents such as effect of diet on gastric and colorectal cancers. Dietary factors might interact in several ways with the genome to protect against cancer. An agent might interact directly with the genome and regulate expression (as a genetic or epigenetic regulator) or indirectly by influencing DNA 'repair' responses and so improve genomic stability. Research now shows that diet-genomic interactions in cancer go beyond interactions with the normal genome and involve enhancement of normal cellular responses to DNA damage such that genome stability is more effectively maintained. Activation of apoptosis may be a key to protection.
机译：癌症是由基因组紊乱和不稳定导致的-异常程度随着肿瘤发生过程的发展而发展。此类基因组不稳定似乎受环境因素控制，这由特定环境因素（肺，皮肤，子宫颈）引起的癌症数量证明，或由更广泛的因素（例如饮食对胃的影响）调节。和大肠癌。饮食因素可能会以多种方式与基因组相互作用以预防癌症。试剂可以直接与基因组相互作用并调节表达（作为遗传或表观遗传调节剂），也可以通过影响DNA的“修复”反应间接地调节表达，从而提高基因组稳定性。现在的研究表明，癌症中饮食基因组的相互作用超出了与正常基因组的相互作用，并涉及增强了正常细胞对DNA损伤的反应，从而更有效地维持了基因组的稳定性。凋亡的激活可能是保护的关键。

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