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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Purifying selection and birth-and-death evolution in the ubiquitin gene family
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Purifying selection and birth-and-death evolution in the ubiquitin gene family

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摘要

Ubiquitin is a highly conserved protein that is encoded by a multigene family. It is generally believed that this gene family is subject to concerted evolution, which homogenizes the member genes of the family. However, protein homogeneity can be attained also by strong purifying selection. We therefore studied the proportion (p(s)) Of synonymous nucleotide differences between members of the ubiquitin gene family from 28 species of fungi, plants, and animals. The results have shown that p(s) is generally very high and is often close to the saturation level, although the protein sequence is virtually identical for all ubiquitins from fungi. plants, and animals. A small proportion of species showed a low level of P-s values, but these values appeared to be caused by recent gene duplication. It was also found that the number of repeat copies of the gene family varies considerably with species, and some species harbor pseudogenes. These observations suggest that the members of this gene family evolve almost independently by silent nucleotide substitution and are subjected to birth-and-death evolution at the DNA level. References: 32

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