Microsatellite evolution inferred from human-chimpanzee genomic sequence alignments.

Webster MT; Smith NG; Ellegren H

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Microsatellite evolution inferred from human-chimpanzee genomic sequence alignments.

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摘要

Most studies of microsatellite evolution utilize long, highly mutable loci, which are unrepresentative of the majority of simple repeats in the human genome. Here we use an unbiased sample of 2,467 microsatellite loci derived from alignments of 5.1 Mb of genomic sequence from human and chimpanzee to investigate the mutation process of tandemly repetitive DNA. The results indicate that the process of microsatellite evolution is highly heterogeneous, exhibiting differences between loci of different lengths and motif sizes and between species. We find a highly significant tendency for human dinucleotide repeats to be longer than their orthologues in chimpanzees, whereas the opposite trend is observed in mononucleotide repeat arrays. Furthermore, the rate of divergence between orthologues is significantly higher at longer loci, which also show significantly greater mutability per repeat number. These observations have important consequences for understanding the molecular mechanisms of microsatellite mutation and for the development of improved measures of genetic distance.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2002年第13期|8748-8753|共6页
作者
Webster MT; Smith NG; Ellegren H;
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作者单位

Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE-752 36 Uppsala, Sweden. matthew.webster;

hysiol.ox.ac.uk;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Evolution; Molecular; Genome; Human; Microsatellite Repeats; Pan troglodytes; 进化; 分子; 基因组; 人; 微随体重复;

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Microsatellite evolution inferred from human-chimpanzee genomic sequence alignments.

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