Perspective: Density matters: The semiconservative replication of DNA.

Hanawalt PC

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Perspective: Density matters: The semiconservative replication of DNA.

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The semiconservative mode of DNA replication was originally documented through the classic density labeling experiments of Matthew Meselson and Franklin W. Stahl, as communicated to PNAS by Max Delbruck in May 1958. The ultimate value of their novel approach has extended far beyond the initial implications from that elegant study, through more than four decades of research on DNA replication, recombination, and repair. I provide here a short historical commentary and then an account of some developments in the field of DNA replication, which closely followed the Meselson-Stahl experiment. These developments include the application of density labeling to discover the repair replication of damaged DNA, a nonconservative replaced.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2004年第52期|17889-17894|共6页
作者
Hanawalt PC;
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作者单位

Department of Biological Sciences, Stanford University, Stanford, CA 94305-5020.;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类基础医学;
关键词
replication; DNA Replication; physical density; Commentary; DNA复制;

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Perspective: Density matters: The semiconservative replication of DNA.

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