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SecA: a potential antimicrobial target

机译:SecA:潜在的抗菌目标

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There is a consensus in the medical profession of the pressing need for novel antimicrobial agents due to issues related to drug resistance. In practice, solutions to this problem to a large degree lie with the identification of new and vital targets in bacteria and subsequently designing their inhibitors. We consider SecA a very promising antimicrobial target. In this review, we compile and analyze information available on SecA to show that inhibition of SecA has a multitude of consequences. Furthermore, we discuss issues critical to the design and evaluation of SecA inhibitors.
机译:由于与抗药性有关的问题,迫切需要新型抗菌剂在医学界已达成共识。实际上,解决该问题的方法很大程度上取决于鉴定细菌中新的重要靶标并随后设计其抑制剂。我们认为SecA是非常有前途的抗菌目标。在这篇综述中,我们汇编和分析了有关SecA的可用信息,以显示抑制SecA具有多种后果。此外,我们讨论了对SecA抑制剂的设计和评估至关重要的问题。

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