Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1.

Shen Y; Luche R; Wei BGordon MLDiltz CDTonks NK

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Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1.

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The mitogen-activated protein kinases (MAPKs) are integral to the mechanisms by which cells respond to physiological stimuli, such as growth factors, hormones, and cytokines, and to a wide variety of environmental stresses. The MAPKs, which are stimulated by phosphorylation of a TXY motif in their activation loop, are components of signal transduction cascades in which sequential activation of protein kinases culminates in their activation and their subsequent phosphorylation of various effector proteins that mediate the physiological response. MAPKs are also subject to dephosphorylation and inactivation, both by enzymes that recognize the residues of the TXY motif independently and by dual specificity phosphatases, which dephosphroylate both Tyr and Ser/Thr residues. We report the identification and characterization of a novel dual specificity phosphatase. Contrary to expectation, this broadly expressed enzyme did not inactivate MAPKs in transient cotransfection assays but instead displayed the capacity to function as a selective activator of the MAPK Jnk, hence the name, Jnk Stimulatory Phosphatase-1 (JSP-1). This study illustrates a new aspect of the regulation of MAPK-dependent signal transduction and raises the possibility that JSP-1 may offer a different perspective to the study of various inflammatory and proliferative disorders associated with dysfunctional Jnk signaling.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2001年第24期|13613-13618|共6页
作者
Shen Y; Luche R; Wei BGordon MLDiltz CDTonks NK;
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作者单位

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.;

ost.tau.ac.il;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Mitogen Activated Protein Kinases metabolism; Phosphoprotein Phosphatase; 磷蛋白磷酸酶; 蛋白质酪氨酸激酶; 蛋白质酪氨酸磷酸酶; 信号传递;

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Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1.

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