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首页> 外文期刊>Macromolecular symposia >Functionalization and application of cellulose microparticles as adsorbents in extracorporeal blood purification
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Functionalization and application of cellulose microparticles as adsorbents in extracorporeal blood purification

机译：纤维素微粒在体外血液净化中作为吸附剂的功能化和应用

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Therapeutic apheresis is established as supportive therapy for various diseases, such as hypercholesterolemia, autoimmune diseases, liver failure, and sepsis. In combined membrane-adsorption systems, the patient's plasma is continuously separated from whole blood by means of a hollow fiber filter, and pathogenic factors are removed from the plasma by selective or specific adsorbents. While adsorbent particles with a size range of 300-800 μm are used in conventional systems, we are currently developing a system based on adsorbent microparticles (1-5 μm), the Microspheres-Based Detoxification System (MDS). The characteristics of the matrix used for immobilization of specific ligands influence the performance of the resulting adsorbents. Desirable matrix characteristics are an open porous structure with an inner surface accessible for target molecules, mechanical stability, narrow particle size distribution, and ease of derivatization. In addition, biocompat-ibility is a critical issue, since the particles are in direct contact with the patient's plasma. Cellulose represents an ideal support matrix, as it combines all the above-mentioned features, and cellulosic polymers are widely applied in medicine and generally regarded as biocompatible. Cellulose microparticles can be activated using e.g. sodium periodate and functionalized with Polymyxin B or anti-tumor necrosis factor (TNF) antibodies to generate specific adsorbents for endotoxins or TNF. In summary, cellulose microparticles represent an excellent matrix as basis for adsorbent development in blood purification.
机译：建立治疗性血液分离是对多种疾病的支持疗法，例如高胆固醇血症，自身免疫性疾病，肝衰竭和败血症。在组合的膜吸附系统中，患者的血浆通过中空纤维过滤器连续从全血中分离出来，并通过选择性或特异性吸附剂从血浆中去除致病因子。在常规系统中使用尺寸范围为300-800μm的吸附剂颗粒时，我们目前正在开发基于吸附剂颗粒（1-5μm）的系统，即基于微球的排毒系统（MDS）。用于固定特定配体的基质的特性会影响所得吸附剂的性能。理想的基质特性是具有目标分子可接近的内表面的开放式多孔结构，机械稳定性，窄的粒度分布以及易于衍生化。另外，生物相容性是关键问题，因为颗粒直接与患者血浆接触。纤维素代表了理想的支持基质，因为它结合了所有上述特征，并且纤维素聚合物广泛应用于医学中，通常被认为是生物相容性的。纤维素微粒可以使用例如碳酸氢钠活化。高碘酸钠，并用多粘菌素B或抗肿瘤坏死因子（TNF）抗体进行功能化，以生成内毒素或TNF的特异性吸附剂。总之，纤维素微粒代表了优异的基质，是血液净化中吸附剂发展的基础。

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