Stimulation of phosphatidylinositol kinase type 1-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2 mu-cargo complexes

Krauss  M; Kukhtina  V; Pechstein  AHaucke  V

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Stimulation of phosphatidylinositol kinase type 1-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2 mu-cargo complexes

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Phosphatidylinositol (4,5)-bisphosphate PI(4,5)P-2 is an important factor for a variety of cellular functions ranging from cell signaling to actin cytoskeletal dynamics and endocytic membrane traffic. Here, we have identified the clathrin adaptor complex AP-2 as a regulator of phosphatidylinositol 4-phosphate 5-kinase (PIPK)-mediated PI(4,5)P2 synthesis. AP-2 directly interacts with the kinase core domain of type I PIPK isozymes via its mu 2-subunit in vitro and in native protein extracts. Endocytic cargo protein binding to mu 2 leads to a potent stimulation of PIPK activity. These data thus identify a positive feedback loop consisting of endocytic cargo proteins, AP-2 mu, and PIPK type I which may provide a specific pool of PI(4,5)P2 dedicated to clathrin/AP-2-dependent receptor internalization.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2006年第32期|11934-11939|共6页
作者
Krauss M; Kukhtina V; Pechstein AHaucke V;
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作者单位

Free Univ Berlin, Inst Chem & Biochem, Dept Membrane Biochem, D-14195 Berlin, Germany;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
phosphoinositides; sorting motifs; clathrin; endocytosis; CLATHRIN-MEDIATED ENDOCYTOSIS; PHOSPHATE KINASE; PLASMA-MEMBRANE; ADAPTER COMPLEX; COATED PITS; PHOSPHOINOSITIDE METABOLISM; NERVE-TERMINALS; I-GAMMA; AP-2; SIGNALS;

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Stimulation of phosphatidylinositol kinase type 1-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2 mu-cargo complexes

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