Estrogen-Induced Alterations in amh and dmrt1 Expression Signal for Disruption in Male Sexual Development in the Zebrafish

RUDIGER W.SCHULZ; JAN BOGERD; RUNE MALE

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Estrogen-Induced Alterations in amh and dmrt1 Expression Signal for Disruption in Male Sexual Development in the Zebrafish

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Dmrtl and amh are genes involved in vertebrate sex differentiation.In this study,we cloned dmrt1 and amh cDNAs in zebrafish(Danio rerio)and investigated the effects of exposure to 17a-ethinylestradiol(EE_2),during early life on their patterns of expression and impact on the subsequent gonadal phenotype.Expression of both amh and dmrt1 in embryos was detected as early as at 1 day post fertilization(dpf)and enhanced expression of amh from 25 dpf was associated with the period of early gonadal differentiation.Sex-dependent differences in enhanced green fluorescent protein transgene expression driven by the promoter of the germ cell-specific vas gene were exploited to show that at 28dpf and 56dpf both amh and dmrt1 mRNA were overexpressed in males compared with females.Exposure during early life to environmentally relevant concentrations of EE_2 had a suppressive effect on the expression of both amh and dmrt1 mRNAs and this was associated with a cessation/retardation in male gonadal sex development.Our findings indicate that estrogen-induced suppression in expression of dmrt1 and amh during early life correlate with subsequent disruptive effects on the sexual phenotype in males.

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《Environmental Science & Technology: ES&T》 |2007年第17期|6305-6310|共6页
作者
RUDIGER W.SCHULZ; JAN BOGERD; RUNE MALE;
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作者单位

Laboratory for Endocrinology,Department of Biology,Faculty of Science,University of Utrecht,Padualaan 8,NL-3584 CH Utrecht,The Netherlands,Department of Molecular Biology,University of Bergen,HiB,Thormoehlensgt.55,N-5020 Bergen,Norway,and Environment;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种英语
中图分类环境化学;
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Estrogen-Induced Alterations in amh and dmrt1 Expression Signal for Disruption in Male Sexual Development in the Zebrafish

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