Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation.

Chan TimothyA; Wang Zhenghe; Dang LongHVogelstein BertKinzler KennethW

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation.

【24h】

Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation.

机译：

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Inactivating mutations of the adenomatous polyposis coli gene (APC) or activating mutations of the beta-catenin gene (CTNNB1) initiate colorectal neoplasia. To address the biochemical and physiologic effects of mutant beta-catenin, we disrupted either the mutant or wild-type CTNNB1 allele in a human colorectal cancer cell line. Cells with only wild-type beta-catenin had decreased colony-forming ability when plated at low density, although their growth was similar to that of parental cells when passaged under routine conditions. Immunohistochemistry and cell-fractionation studies suggested that mutant beta-catenin activity was distinguished primarily by cellular localization and not by protein degradation. Surprisingly, we found mutant beta-catenin bound less well to E-cadherin than did wild-type beta-catenin, and the membranous localization of wild-type and mutant beta-catenin was accordingly distinct. These findings pose several challenges to current models of APC/beta-catenin function.

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2002年第12期|8265-8270|共6页
作者
Chan TimothyA; Wang Zhenghe; Dang LongHVogelstein BertKinzler KennethW;
展开▼
作者单位

The Sidney Kimmel Comprehensive Cancer Center, the Johns Hopkins Medical Institutions, 1650 Orleans Street, Baltimore, MD 21231, USA.;

itt.edu;

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Cytoskeletal Proteins; Chromosomes; Artificial; Bacterial; Recombinant Proteins; 细胞支架蛋白质类;

相似文献

外文文献
中文文献

1. Long Noncoding RNA LINC01006 Facilitates Cell Proliferation, Migration, and Epithelial-Mesenchymal Transition in Lung Adenocarcinoma via Targeting the MicroRNA 129-2-3p/CTNNB1 Axis and Activating Wnt/beta-Catenin Signaling Pathway [J] . Zhang Yu, Liu Hailin, Zhang QiangZhang Zhenfa Molecular and Cellular Biology . 2021,第6期

机译：Long Noncoding RNA LINC01006 Facilitates Cell Proliferation, Migration, and Epithelial-Mesenchymal Transition in Lung Adenocarcinoma via Targeting the MicroRNA 129-2-3p/CTNNB1 Axis and Activating Wnt/beta-Catenin Signaling Pathway
2. Analyses of the effects of Rck2p mutants on Pbs2p(DD)-induced toxicity in Saccharomyces cervisiae identify a MAP kinase docking motif, and unexpected functional inactivation due to acidic substitution of T379 [J] . Jiang L, Niu S, Clines KLBurke DJSturgill TW Molecular biology reports . 2004,第2期

机译：Analyses of the effects of Rck2p mutants on Pbs2p(DD)-induced toxicity in Saccharomyces cervisiae identify a MAP kinase docking motif, and unexpected functional inactivation due to acidic substitution of T379
3. Research resource: expression profiling reveals unexpected targets and functions of the human steroid receptor RNA activator (SRA) gene. [J] . Foulds CE, Tsimelzon A, Long WLe ATsai SYTsai MJOMalley BW Molecular Endocrinology . 2010,第5期

机译：Research resource: expression profiling reveals unexpected targets and functions of the human steroid receptor RNA activator (SRA) gene.
4. Trichoblastic carcinosarcoma with panfollicular differentiation (panfollicular carcinosarcoma) and CTNNB1 (beta‐catenin) mutation [O] . Jenny Giang, Asok Biswas, Antien L. Mooyaart, 2020

机译：血细胞分化（胰癌癌）和CTNNB1（Beta-catenin）突变的血管间癌瘤

Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation.

摘要

著录项

相似文献

相关主题

期刊订阅