Developmental expression of functional cyclooxygenases in zebrafish.

Grosser Tilo; Yusuff Shamila; Cheskis EllinaPack MichaelAFitzGerald GarretA

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Developmental expression of functional cyclooxygenases in zebrafish.

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Study of the cyclooxygenases (COXs) has been limited by the role of COX-2 in murine reproduction and renal organogenesis. We sought to characterize COX expression and function in zebrafish (z). Full-length cDNAs of zCOX-1 and zCOX-2 were cloned and assigned to conserved regions of chromosomes 5 and 2, respectively. The deduced proteins are 67 homologous with their human orthologs. Prostaglandin (PG) E(2) is the predominant zCOX product detected by mass spectrometry. Pharmacological inhibitors demonstrate selectivity when directed against heterologously expressed zCOX isoforms. Zebrafish thrombocyte aggregation ex vivo and hemostasis in vivo are sensitive to inhibition of zCOX-1, but not zCOX-2. Both zCOXs were widely expressed during development, and knockdown of zCOX-1 causes growth arrest during early embryogenesis. zCOX-1 is widely evident in the embryonic vasculature, whereas zCOX-2 exhibits a more restricted pattern of expression. Both zCOX isoforms are genetically and functionally homologous to their mammalian orthologs. The zebrafish affords a tractable model system for the study of COX biology and development.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2002年第12期|8418-8423|共6页
作者
Grosser Tilo; Yusuff Shamila; Cheskis EllinaPack MichaelAFitzGerald GarretA;
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作者单位

Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104, USA.;

itt.edu;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Gene Expression Regulation; Developmental; Enzymologic; 基因表达调控; 发育期; 酶学; 同工酶类; 前列腺素内过氧化物合酶;

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Developmental expression of functional cyclooxygenases in zebrafish.

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