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首页> 外文期刊>Frontiers in bioscience: a journal and virtual library >Angiogenic factors and preeclampsia.
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Angiogenic factors and preeclampsia.

机译：血管生成因子和先兆子痫。

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Preeclampsia is a major cause of maternal and neonatal morbidity and mortality worldwide. Although the etiology of preeclampsia is still unclear, recent studies suggest that its major phenotypes, hypertension and proteinuria, may be due to an excess of circulating anti-angiogenic growth factors, most notably soluble fms-like tyrosine kinase 1 (sFlt1) and soluble endoglin (sEng). sFlt1 is an endogenous protein that is produced by the placenta. sFlt1 is able to bind to the angiogenic growth factors vascular endothelial growth factor and placental growth factor, thereby neutralizing their functions. High serum concentrations of sFlt1 and low concentrations of free vascular endothelial growth factor and free placental growth factor have been observed during and prior to clinical manifestation of preeclampsia. More recently, serum levels of sEng were also shown to be significantly elevated in preeclamptic women and levels of sEng correlated strongly with disease severity. Therefore, measurement of sFlt1 andsEng in the maternal circulation may be a useful diagnostic and screening tool for preeclampsia. The availability of such a test to predict preeclampsia would have significant impact on current obstetrical care and may help reduce preeclampsia-induced morbidity and mortality. This review will focus on the role of angiogenic factors in normal and abnormal placental development and indicate how measurement of circulating angiogenic factors may help identify women at risk of preeclampsia.
机译：子痫前症是全世界孕产妇和新生儿发病率和死亡率的主要原因。尽管先兆子痫的病因尚不清楚，但最近的研究表明其主要表型，高血压和蛋白尿可能是由于循环中的抗血管生成生长因子过多，最明显的是可溶性fms样酪氨酸激酶1（sFlt1）和可溶性内皮糖蛋白（sEng）。 sFlt1是胎盘产生的内源性蛋白质。 sFlt1能够与血管生成生长因子，血管内皮生长因子和胎盘生长因子结合，从而中和其功能。在先兆子痫的临床表现期间和之前，已观察到高浓度的sFlt1血清和低浓度的游离血管内皮生长因子和游离胎盘生长因子。最近，子痫前期妇女的血清sEng水平也显示出明显升高，并且sEng的水平与疾病的严重程度密切相关。因此，测量母体循环中的sFlt1和sEng可能是子痫前期的有用诊断和筛查工具。这种能够预测先兆子痫的检测方法将对当前的产科护理产生重大影响，并可能有助于降低先兆子痫引起的发病率和死亡率。这篇综述将着重于血管生成因子在正常和异常胎盘发育中的作用，并指出对循环血管生成因子的测量如何帮助识别处于先兆子痫风险的女性。

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