The role of n-3 polyunsaturated fatty acids in brain: modulation of rat brain gene expression by dietary n-3 fatty acids.

Kitajka Klara; Puskas LaszloG; Zvara AgnesHackler Laszlo JrBarcelo-Coblijn GwendolynYeo YoungKFarkas Tibor

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The role of n-3 polyunsaturated fatty acids in brain: modulation of rat brain gene expression by dietary n-3 fatty acids.

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Rats were fed either a high linolenic acid (perilla oil) or high eicosapentaenoic + docosahexaenoic acid (fish oil) diet (8), and the fatty acid and molecular species composition of ethanolamine phosphoglycerides was determined. Gene expression pattern resulting from the feeding of n-3 fatty acids also was studied. Perilla oil feeding, in contrast to fish oil feeding, was not reflected in total fatty acid composition of ethanolamine phosphoglycerides. Levels of the alkenylacyl subclass of ethanolamine phosphoglycerides increased in response to feeding. Similarly, levels of diacyl phosphatidylethanolamine molecular species containing docosahexaenoic acid (18:0/22:6) were higher in perilla-fed or fish oil-fed rat brains whereas those in ethanolamine plasmalogens remained unchanged. Because plasmalogen levels in the brains of rats fed a n-3 fatty acid-enriched diet increased, it is plausible, however, that docosahexaenoic acid taken up from the food or formed from linolenic acid was deposited in this phospholipid subclass. Using cDNA microarrays, 55 genes were found to be overexpressed and 47 were suppressed relative to controls by both dietary regimens. The altered genes included those controlling synaptic plasticity, cytosceleton and membrane association, signal transduction, ion channel formation, energy metabolism, and regulatory proteins. This effect seems to be independent of the chain length of fatty acids, but the n-3 structure appears to be important. Because n-3 polyunsaturated fatty acids have been shown to play an important role in maintaining normal mental functions and docosahexaenoic acid-containing ethanolamine phosphoglyceride (18:0/22:6) molecular species accumulated in response to n-3 fatty acid feeding, a casual relationship between the two events can be surmised.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2002年第5期|2619-2624|共6页
作者
Kitajka Klara; Puskas LaszloG; Zvara AgnesHackler Laszlo JrBarcelo-Coblijn GwendolynYeo YoungKFarkas Tibor;
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作者单位

Institute of Biochemistry, and DNA-Chip Laboratory, Biological Research Center, Hungarian Academy of Sciences, P.O. Box 521, H-6701 Szeged, Hungary.;

ublic.wh.hb.cn;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
5; 8; 11; 14; 17-Eicosapentaenoic Acid; Brain; Dietary Fats; Docosahexaenoic Acids; 17-花生五烯酸; 脑; 膳食脂肪类; 二十二碳六烯酸类; 基因表达; α亚麻酸;

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1. Diet (n-3) Polyunsaturated Fatty Acid Content and Parity Interact to Alter Maternal Rat Brain Phospholipid Fatty Acid Composition. [J] . Levant Beth, Ozias Marlies K., Carlson Susan E. The Journal of Nutrition: Official Organ of the American Institute of Nutrition . 2006,第8期

机译：Diet (n-3) Polyunsaturated Fatty Acid Content and Parity Interact to Alter Maternal Rat Brain Phospholipid Fatty Acid Composition.
2. Dietary intake and status of n-3 polyunsaturated fatty acids in a population of fish-eating and non-fish-eating meat-eaters, vegetarians, and vegans and the product-precursor ratio (corrected) of alpha-linolenic acid to long-chain n-3 polyunsaturated fatty acids: results from the EPIC-Norfolk cohort. [J] . Welch AA, Shakya Shrestha S, Lentjes MAWareham NJKhaw KT The American Journal of Clinical Nutrition: Official Journal of the American Society for Clinical Nutrition . 2010,第5期

机译：Dietary intake and status of n-3 polyunsaturated fatty acids in a population of fish-eating and non-fish-eating meat-eaters, vegetarians, and vegans and the product-precursor ratio (corrected) of alpha-linolenic acid to long-chain n-3 polyunsaturated fatty acids: results from the EPIC-Norfolk cohort.
3. Combined Deficiency of Iron and (n-3) Fatty Acids in Male Rats Disrupts Brain Monoamine Metabolism and Produces Greater Memory Deficits Than Iron Deficiency or (n-3) Fatty Acid Deficiency Alone. [J] . Jeannine Baumgartner, Cornelius M Smuts, Linda MalanMyrtha ArnoldBenjamin K YeeLaura E BiancoMark V BoekschotenMichael MüllerWolfgang LanghansRichard F HurrellMichael B Zimmermann The Journal of Nutrition: Official Organ of the American Institute of Nutrition . 2012,第8期

机译：Combined Deficiency of Iron and (n-3) Fatty Acids in Male Rats Disrupts Brain Monoamine Metabolism and Produces Greater Memory Deficits Than Iron Deficiency or (n-3) Fatty Acid Deficiency Alone.
4. Correction: ingestion of a single serving of saury alters postprandial levels of plasma n-3 polyunsaturated fatty acids and long-chain monounsaturated fatty acids in healthy human adults [O] . Yang Zhi-Hong, Miyahara Hiroko, Takeo Jiro, 2012

机译：Correction: ingestion of a single serving of saury alters postprandial levels of plasma n-3 polyunsaturated fatty acids and long-chain monounsaturated fatty acids in healthy human adults

The role of n-3 polyunsaturated fatty acids in brain: modulation of rat brain gene expression by dietary n-3 fatty acids.

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