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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >A piggyBac route to transgenic honeybees
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A piggyBac route to transgenic honeybees

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The honeybee Apis mellifera is one of the most recognized and revered insect species throughout human history. The economic impact of the honeybee as an essential pollinator of key crops is estimated to be in the range of billions of dollars per year. The honeybee also serves as a powerful animal model for studies of the evolution and regulation of social behaviors at the endocrine, cellular, genomic, and molecular levels (1). However, until recently, studies of molecular processes that underlie behavior in the honeybee have mainly relied on correlative genomic studies of brain gene expression patterns (2). Nevertheless, establishing a causal relationship between specific genetic loci and phenotypes has been hindered by the lack of robust and reliable methods to manipulate honeybee gene expression, the generation of transgenes, and genome editing. In PNAS, Schulte et al. (3) provide, to my knowledge, the first evidence that heritable germ-line manipulations of the honeybee genome are feasible by using engineered transposable elements. These welcome technical advances are likely to transform the fields of sociobiology and apiculture (commercial beekeeping) by helping investigators to establish causal relationships between genes and behavioral, developmental, and diseaserelated phenotypes.

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