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首页> 外文期刊>Mathematical medicine and Biology: a journal of the IMA >Mathematically modelling the effects of counting factor in Dictyostelium discoideum
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Mathematically modelling the effects of counting factor in Dictyostelium discoideum

机译:数学计算盘基网柄菌计数因子的作用

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摘要

Size regulation is a crucial feature in many biological systems, with misregulation leading to dysplasia or hyperplasia. The recent discovery of counting factor (CF) in Dictyostelium discoideum will lead to a greater understanding of how the system regulates the size of a group of cells. In this paper we mathematically model the known effects of CF using two different models: a cellular automata model and a discrete continuum hybrid model. With the use of these models we are able to understand how modulation of adhesion and motile forces by CF can facilitate stream breakup. In addition, the modelling suggests a new possible mechanism for stream breakup involving the frequency of cell reorientation.
机译:尺寸调节是许多生物系统的关键特征,调节不当会导致发育异常或增生。盘基网柄菌中计数因子(CF)的最新发现将使人们对该系统如何调节一组细胞的大小有更深入的了解。在本文中,我们使用两种不同的模型对CF的已知效应进行数学建模:元胞自动机模型和离散连续体混合模型。通过使用这些模型,我们能够了解CF对粘附力和动力的调节如何促进流分裂。另外,该建模提出了一种新的可能的流分裂机制,涉及细胞重新定向的频率。

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