CmC(A/T)GG DNA methylation in mature B cell lymphoma gene silencing.

Malone CS; Miner MD; Doerr JRJackson JPJacobsen SEWall RTeitell M

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CmC(A/T)GG DNA methylation in mature B cell lymphoma gene silencing.

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DNA methylation has been linked to gene silencing in cancer. Primary effusion lymphoma (PEL) and myeloma are lymphoid malignancies that arise from terminally differentiated B cells. Interestingly, PEL do not express immunoglobulins or most B lineage-specific genes. The B cell-specific B29 (Igbeta/CD79b) gene is silenced in PEL and some myelomas but is expressed in other normal and malignant B cells. B29 expression was reactivated in PEL by demethylating and histone deacetylase inhibiting treatments. Bisulfite sequencing revealed two types of DNA methylation in silenced B29 promoters: at conventional CpG and at CC(A/T)GG B29 promoter sites. The pattern of methylated CpG ((m)CpG) and C(m)C(A/T)GG B29 promoter methylation observed was similar to that recently reported for epigenetic silencing of an integrated retrovirus. Methylation of C(m)C(A/T)GG sites in the B29 promoter significantly repressed in vivo transcriptional activity. Also, methylation of a central conserved C(m)CTGG B29 promoter site blocked the binding of early B cell factor. This methylated motif formed DNA-protein complexes with nuclear extracts from all cell types examined. Therefore, C(m)C(A/T)GG methylation may represent an important type of epigenetic marker on mammalian DNA that impacts transcription by altering DNA-protein complex formation.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2001年第18期|10404-10409|共6页
作者
Malone CS; Miner MD; Doerr JRJackson JPJacobsen SEWall RTeitell M;
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作者单位

Department of Microbiology and Immunology, Jonsson Comprehensive Cancer Center, University of California, Center for the Health Sciences, Los Angeles, CA 90095, USA.;

artners.org;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
DNA Methylation; Gene Silencing; Lymphoma; B-Cell; Antigens; CD; DNA Primers; DNA甲基化; 淋巴瘤; B细胞;

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CmC(A/T)GG DNA methylation in mature B cell lymphoma gene silencing.

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