Myelin-associated glycoprotein mediates membrane fusion and entry of neurotropic herpesviruses

Suenaga T; Satoh T; Somboonthum PKawaguchi YMori YArase H

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Myelin-associated glycoprotein mediates membrane fusion and entry of neurotropic herpesviruses

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Varicella-zoster virus (VZV) and herpes simplex virus (HSV) are prevalent neurotropic herpesviruses that cause various nervous system diseases. Similar to other enveloped viruses, membrane fusion is an essential process for viral entry. Therefore, identification of host molecules that mediate membrane fusion is important to understand the mechanism of viral infection. Here, we demonstrate that myelin-associated glycoprotein (MAG), mainly distributed in neural tissues, associates with VZV glycoprotein B (gB) and promotes cell-cell fusion when coexpressed with VZV gB and gH/gL. VZV preferentially infected MAG-transfected oligodendroglial cells. MAG also associated with HSV-1 gB and enhanced HSV-1 infection of promyelocytes. These findings suggested that MAG is involved in VZV and HSV infection of neural tissues.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2010年第2期|866-871|共6页
作者
Suenaga T; Satoh T; Somboonthum PKawaguchi YMori YArase H;
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作者单位

Laboratory of Virology and Vaccinology, Department of Biomedical Research, National Institute of Biomedical Innovation, Ibaraki, Osaka 567-0085, Japan;

Department of Immunochemistry, Research Institute for Microbial Diseases Osaka University, Suita, Osaka 565-0871, Japan;

Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
herpes simplex virus; neurotropism; membrane fusion; Varicella-zoster virus; virus entry;

Myelin-associated glycoprotein mediates membrane fusion and entry of neurotropic herpesviruses

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