Fcγ receptor IIB (FcγRIIB) maintains humoral tolerance in the human immune system in vivo

Baerenwaldt A.; Lux A.; Danzer H.Spriewald B.M.Ullrich E.Heidkamp G.Dudziak D.Nimmerjahn F.

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Fcγ receptor IIB (FcγRIIB) maintains humoral tolerance in the human immune system in vivo

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Maintenance of immunological tolerance is crucial to prevent development of autoimmune disease. The production of autoantibodies is a hallmark of many autoimmune diseases and studies in mouse model systems suggest that inhibitory signaling molecules may be important checkpoints of humoral tolerance. By generating humanized mice with normal and functionally impaired Fcγ receptor IIB (FcγRIIB) variants, we show that the inhibitory Fcγ-receptor is a checkpoint of humoral tolerance in the human immune system in vivo. Impaired human FcγRIIB function resulted in the generation of higher levels of serum immunoglobulins, the production of different autoantibody specificities, and a higher proportion of human plasmablasts and plasma cells in vivo. Our results suggest that the inhibitory FcγRIIB may be an important checkpoint of humoral tolerance in the human immune system.

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《Proceedings of the National Academy of Sciences of the United States of America.》 |2011年第46期|18772-18777|共6页
作者
Baerenwaldt A.; Lux A.; Danzer H.Spriewald B.M.Ullrich E.Heidkamp G.Dudziak D.Nimmerjahn F.;
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作者单位

Department of Biology, Institute of Genetics, University of Erlangen-Nürnberg, 91058 Erlangen, Germany;

Department of Hematology and Oncology, University Hospital of Erlangen, 91054 Erlangen, Germany;

Department of Dermatology, Nikolaus-Fiebiger-Centre for Molecular Medicine, University Hospital of Erlangen, 91054 Erlangen, Germany;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Fc-receptor; Systemic lupus erythematosus;

Fcγ receptor IIB (FcγRIIB) maintains humoral tolerance in the human immune system in vivo

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