FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis.

Ishii H; Vecchione A; Murakumo YBaldassarre GNumata STrapasso FAlder HBaffa RCroce CM

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FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis.

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The FEZ1/LZTS1 gene maps to chromosome 8p22, a region that is frequently deleted in human tumors. Alterations in FEZ1/LZTS1 expression have been observed in esophageal, breast, and prostate cancers. Here, we show that introduction of FEZ1/LZTS1 into Fez1/Lzts1-negative cancer cells results in suppression of tumorigenicity and reduced cell growth with accumulation of cells at late S-G(2)/M stage of the cell cycle. Fez1/Lzts1 protein is hyperphosphorylated by cAMP-dependent kinase during cell-cycle progression. We found that Fez1/Lzts1 is associated with microtubule components and interacts with p34(cdc2) at late S-G(2)/M stage in vivo. Present data show that FEZ1/LZTS1 inhibits cancer cell growth through regulation of mitosis, and that its alterations result in abnormal cell growth.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2001年第18期|10374-10379|共6页
作者
Ishii H; Vecchione A; Murakumo YBaldassarre GNumata STrapasso FAlder HBaffa RCroce CM;
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作者单位

Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107-5799, USA.;

obox.upenn.edu;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Chromosomes; Human; Pair 8; DNA-Binding Proteins; Neoplasms; FEZ1-protein; 染色体; 人; 8对; DNA结合蛋白质类; 肿瘤;

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FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis.

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