FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex

Ikenouchi J; Umeda M

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FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex

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The Par-3/Par-6/aPKC/Cdc42 complex regulates the conversion of primordial adherens junctions (AJs) into belt-like AJs and the formation of linear actin cables during epithelial polarization. However, the mechanisms by which this complex functions are not well elucidated. In the present study, we found that activation of Arf6 is spatiotemporally regulated as a downstream signaling pathway of the Par protein complex. When primordial AJs are formed, Par-3 recruits a scaffolding protein, termed the FERM domain containing 4A (FRMD4A). FRMD4A connects Par-3 and the Arf6 guanine-nucleotide exchange factor (GEF), cytohesin-1. We propose that the Par-3/FRMD4A/cytohesin-1 complex ensures accurate activation of Arf6, a central player in actin cytoskeleton dynamics and membrane trafficking, during junctional remodeling and epithelial polarization.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2010年第2期|748-753|共6页
作者
Ikenouchi J; Umeda M;
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作者单位

Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
adherens junction; tight junction; cell polarity; epithelial cells; cytohesin;

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专利

1. Phosphorylation of the par polarity complex protein Par3 at serine 962 is mediated by aurora a and regulates its function in neuronal polarity. [J] . Khazaei MR, Puschel AW The Journal of biological chemistry . 2009,第48期

机译：Phosphorylation of the par polarity complex protein Par3 at serine 962 is mediated by aurora a and regulates its function in neuronal polarity.
2. Author Correction: Apical–basal polarity inhibits epithelial–mesenchymal transition and tumour metastasis by PAR-complex-mediated SNAI1 degradation [J] . Hae-YunJung, LaurentFattet, Jeff H.TsaiTaketoshiKajimotoQiangChangAlexandra C.NewtonJingYang Nature cell biology . 2023,第9期

机译：Author Correction: Apical–basal polarity inhibits epithelial–mesenchymal transition and tumour metastasis by PAR-complex-mediated SNAI1 degradation
3. Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates nitric oxide-induced activator protein-1 activation in human bronchial epithelial cells. [J] . Jibiki I, Hashimoto S, Maruoka SGon YMatsuzawa ANishitoh HIchijo HHorie T American journal of respiratory and critical care medicine . 2003,第6期

机译：Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates nitric oxide-induced activator protein-1 activation in human bronchial epithelial cells.
4. FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex [O] . Junichi Ikenouchi, Masato Umeda 2010

机译：FRMD4A通过将Arf6激活与PAR复合物连接来调节上皮极性
5. FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex [O] . Ikenouchi, Junichi, Umeda, Masato 2010

机译：FRMD4A通过将Arf6激活与PAR复合物连接来调节上皮极性
6. CONTRIBUTION A L'ANALYSE PAR ACTIVATION DES GAZ RARES.nCONTRIBUTION A L'ANALYSE DE L'OXYDE DE CARBONE ET DE LA VAPEUR D'EAU DANS LES GAZ.; [R] . Jean DIEBOLT 1964

机译：贡献a L'aNaLYZE paR aCTIVaTION DEs GaZ RaREs.nCONTRIBUTION a L'aNaLYZE DE L'OXYDE DE CaRBONE ET DE La VapEUR D'EaU DaNs LEs GaZ。

FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex

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