Do Arsenosugars Pose a Risk to Human Health? The Comparative Toxicities of a Trivalent and Pentavalent Arsenosugar

Paul Andrewes; David M.DEmarini; Kunihiro FunasakaKathleen WallaceVivian W.M.LaiWilliam R.ChllenKirk T.Kitchin

首页> 外文期刊>Environmental Science & Technology: ES&T >Do Arsenosugars Pose a Risk to Human Health? The Comparative Toxicities of a Trivalent and Pentavalent Arsenosugar

【24h】

Do Arsenosugars Pose a Risk to Human Health? The Comparative Toxicities of a Trivalent and Pentavalent Arsenosugar

机译：

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Seafood frequently contains high concentrations of arsenic (-10-100 mg/kg dry weight).In marine algae (seaweed),this arsenic occurs predominantly as ribose derivatives known collectively as arsenosugars.Although it is clear that arsenosugars are not acutely toxic,there is a possibility of arsenosugars having slight chronic toxicity.In general,trivalent arsenicals are more toxic than their pentavalent counterparts,so in this work we examine the hypothesis that trivalent arsenosugars might be significantly more toxic than pentavalent arsenosugars in vitro.We compared the in vitro toxicity of (R)-2,3-dihydroxypropyl-5-deoxy-5-dimethylarsinoyl-beta-D-riboside,a pentavalent arsenosugar,to that of its trivalent counterpart,(R)-2,3-dihydroxypropyl-5-deoxy-5-dimethylarsino-beta-D-riboside.The trivalent arsenosugar nicked plasmid DNA,whereas the pentavalent arsenosugar did not.The trivalent arsenosugar was more cytotoxic (ICso=200muM,48 h exposure)than its pentavalent counterpart (IC_(50)>6000 muM,48 h exposure)in normal human epidermal keratinocytes in vitro as determined via the neutral red uptake assay.However,both the trivalent and the pentavalent arsenosugars were significantly less toxic than MMA(III),DMA(III),and arsenate.Neither the pentavalent arsenosugar nor the trivalent arsenosugar were mutagenic in Salmonella TA104.The trivalent arsenosugar was readily formed by reaction of the pentavalent arsenosugar with thiol compounds,including,cysteine,glutathione,and dithioery-thritol.This work suggests that the reduction of pentavalent arsenosugars to trivalent arsenosugars in biology might have environmental consequences,especially because seaweed consumption is a significant environmental source for human exposure to arsenicals.

著录项

来源
《Environmental Science & Technology: ES&T》 |2004年第15期|4140-4148|共9页
作者
Paul Andrewes; David M.DEmarini; Kunihiro FunasakaKathleen WallaceVivian W.M.LaiWilliam R.ChllenKirk T.Kitchin;
展开▼
作者单位

Environmental Carcinogenesis Division,National Health and Environmental Effects Research Laboratory,Office of Research and Development,U.S.Environmental Protection Agency,Research Triangle Park,North Carolina 27711,Department of Atmospheric EnvironmeEnvir;

Environmental Carcinogenesis Division,National Health and Environmental Effects Research Laboratory,Office of Research and Development,U.S.Environmental Protection Agency,Research Triangle Park,North Carolina 27711,Department of Atmospheric Environme;

展开▼
收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类环境化学;
关键词

Do Arsenosugars Pose a Risk to Human Health? The Comparative Toxicities of a Trivalent and Pentavalent Arsenosugar

摘要

著录项

相关主题

期刊订阅