The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum.

Breckenridge DavidG; Nguyen Mai; Kuppig StephanReth MichaelShore GordonC

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The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum.

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BAP31 is an integral protein of the endoplasmic reticulum membrane and a substrate of caspase-8. Here, we describe the procaspase-8 isoform, procaspase-8L, which is ubiquitously expressed and selectively recruited to the BAP31 complex in response to apoptotic signaling by E1A. Procaspase-8L is characterized by the N-terminal extension (Nex) domain, which extends procaspase-8/a at the N terminus and is required for selective association of procaspase-8L with the BAP31 complex. Gene deletion identified BAP31 and related BAP29 as required for processing of procaspase-8L in response to E1A, by a FADD-independent mechanism that was blocked by BCL-2. Further, Bap29,31 deletion, as well as a Nex-domain dominant-negative mutant, curtailed the activation of downstream caspases (IETDase and DEVDase) and cell death in response to E1A. Preferential recruitment of procaspase-8L by the BAP31 complex at the endoplasmic reticulum suggests an additional pathway for regulating initiator caspase-8 during apoptosis.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2002年第7期|4331-4336|共6页
作者
Breckenridge DavidG; Nguyen Mai; Kuppig StephanReth MichaelShore GordonC;
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作者单位

Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, Montreal, QC, Canada H3G 1Y6.;

ublic.wh.hb.cn;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Caspases; Endoplasmic Reticulum; Enzyme Precursors; Isoenzymes; Proteins; Caspase类; 内质网; 酶前体; 同工酶类; 蛋白质类;

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机译：procaspase-8亚型procaspase-8L在内质网募集到BAP31复合体
5. The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum [O] . Breckenridge, David G., Nguyen, Mai, Kuppig, Stephan, 2002

机译：procaspase-8亚型，procaspase-8L，在内质网募集到BAP31复合体

The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum.

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