Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia.

Shin J; Cho H; Hwang SWJung JShin CYLee SYKim SHLee MGChoi YHKim JHaber NAReichling DBKhasar SLevine JDOh U

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Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia.

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The capsaicin-sensitive vanilloid receptor (VR1) was recently shown to play an important role in inflammatory pain (hyperalgesia), but the underlying mechanism is unknown. We hypothesized that pain-producing inflammatory mediators activate capsaicin receptors by inducing the production of fatty acid agonists of VR1. This study demonstrates that bradykinin, acting at B2 bradykinin receptors, excites sensory nerve endings by activating capsaicin receptors via production of 12-lipoxygenase metabolites of arachidonic acid. This finding identifies a mechanism that might be targeted in the development of new therapeutic strategies for the treatment of inflammatory pain.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2002年第15期|10150-10155|共6页
作者
Shin J; Cho H; Hwang SWJung JShin CYLee SYKim SHLee MGChoi YHKim JHaber NAReichling DBKhasar SLevine JDOh U;
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作者单位

Sensory Research Center, National Creative Research Initiatives, Seoul National University, San 56-1, Shinlim, Kwanak-Gu, Seoul 151-742, Korea.;

rodigy.net.;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Arachidonate 12-Lipoxygenase; Bradykinin; Ganglia; Spinal; Hyperalgesia; 花生四烯酸盐12-脂氧合酶; 缓激肽; 神经节; 脊; 痛觉过敏; 神经元; 传入;

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Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia.

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