The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae.

Nautiyal S; DeRisi JL; Blackburn EH

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The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae.

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Loss of the protective function of telomeres has previously been hypothesized to cause a DNA damage response. Here, we report a genome-wide expression response, the telomerase deletion response (TDR), that occurs when telomeres can no longer be maintained by telomerase. The TDR shares features with other DNA damage responses and the environmental stress response. Unexpectedly, another feature of the TDR is the up-regulation of energy production genes, accompanied by a proliferation of mitochondria. Finally, a discrete set of genes, the "telomerase deletion signature", is uniquely up-regulated in the TDR but not under other conditions of stress and DNA damage that have been reported. The telomerase deletion signature genes define new candidates for involvement in cellular responses to altered telomere structure or function.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2002年第14期|9316-9321|共6页
作者
Nautiyal S; DeRisi JL; Blackburn EH;
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作者单位

Department of Biochemistry, University of California, Box 0448, San Francisco, CA 94143, USA.;

rodigy.net.;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Genome; Fungal; Saccharomyces cerevisiae; Telomerase; 基因组; 真菌; 酵母菌; 酿酒; 端粒; 末端转移酶;

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The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae.

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