A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors.

Poellinger L

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A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors.

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The dioxin/aryl hydrocarbon receptor (AhR) functions as a ligand-activated transcription factor regulating transcription of a battery of genes encoding xenobiotic metabolizing enzymes. Known receptor ligands are environmental pollutants including polycyclic aromatic hydrocarbons and polychlorinated dioxins. Loss-of-function (gene-disruption) studies in mice have demonstrated that the AhR is involved in toxic effects of dioxins but have not yielded unequivocal results concerning the physiological function of the receptor. Gain-of-function studies therefore were performed to unravel the biological functions of the AhR. A constitutively active AhR expressed in transgenic mice reduced the life span of the mice and induced tumors in the glandular part of the stomach, demonstrating the oncogenic potential of the AhR and implicating the receptor in regulation of cell proliferation.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2002年第15期|9990-9995|共6页
作者
Poellinger L;
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作者单位

Department of Cell and Molecular Biology, Institute of Environmental Medicine, Department of Oncology-Pathology, and Microbiology and Tumor Biology Center, Karolinska Institute, S-171 77 Stockholm, Sweden;

and Department of Biochemistry, University o;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
receptor; Receptors; Aryl Hydrocarbon; Tetrachlorodibenzodioxin; Stomach; 受体; 芳基烃; 四氯二苯并二恶辛; 胃;

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A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors.

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