Hyporesponsiveness of SPRET/Ei mice to lethal shock induced by tumor necrosis factor and implications for a TNF-based antitumor therapy.

Staelens J; Wielockx B; Puimege LVan Roy FGuenet JLLibert C

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Hyporesponsiveness of SPRET/Ei mice to lethal shock induced by tumor necrosis factor and implications for a TNF-based antitumor therapy.

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Tumor necrosis factor (TNF) is a central mediator in lethal shock and an interesting cytokine for anticancer therapy. To inhibit TNF-induced lethal shock, it is important to identify protective genes. Here we demonstrate that the SPRET/Ei mouse strain, derived from Mus spretus, exhibits an extremely dominant resistance to TNF-induced lethal inflammation. An interspecific backcross experiment revealed that the TNF hyporesponse is linked to loci on chromosomes 2, 6, and 11. Treatment of inoculated tumors with TNF and IFN-gamma leads to regression and a highly reduced toxicity in (C57BL/6 x SPRET/Ei)F(1) mice.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2002年第14期|9340-9345|共6页
作者
Staelens J; Wielockx B; Puimege LVan Roy FGuenet JLLibert C;
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作者单位

Department of Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology and Ghent University, K. L. Ledeganckstraat 35, B-9000 Ghent, Belgium.;

ost.cz;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Shock; Tumor Necrosis Factor; 休克; 肿瘤坏死因子;

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机译：Response of interleukin‐6‐deficient mice to tumor necrosis factor‐induced metabolic changes and lethality
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Hyporesponsiveness of SPRET/Ei mice to lethal shock induced by tumor necrosis factor and implications for a TNF-based antitumor therapy.

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