The GSK3-like kinase BIN2 phosphorylates and destabilizes BZR1, a positive regulator of the brassinosteroid signaling pathway in Arabidopsis.

He JX; Yang Y; Wang ZY

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The GSK3-like kinase BIN2 phosphorylates and destabilizes BZR1, a positive regulator of the brassinosteroid signaling pathway in Arabidopsis.

【24h】

The GSK3-like kinase BIN2 phosphorylates and destabilizes BZR1, a positive regulator of the brassinosteroid signaling pathway in Arabidopsis.

机译：

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Brassinosteroids (BRs) are a class of steroid hormones essential for normal growth and development in plants. BR signaling involves the cell-surface receptor BRI1, the glycogen synthase kinase-3-like kinase BIN2 as a negative regulator, and nuclear proteins BZR1 and BZR2/BES1 as positive regulators. The interactions among these components remain unclear. Here we report that BRs induce dephosphorylation and accumulation of BZR1 protein. Experiments using a proteasome inhibitor, MG132, suggest that phosphorylation of BZR1 increases its degradation by the proteasome machinery. BIN2 directly interacts with BZR1 in yeast two-hybrid assays, phosphorylates BZR1 in vitro, and negatively regulates BZR1 protein accumulation in vivo. These results strongly suggest that BIN2 phosphorylates BZR1 and targets it for degradation and that BR signaling causes BZR1 dephosphorylation and accumulation by inhibiting BIN2 activity.

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2002年第15期|10185-10190|共6页
作者
He JX; Yang Y; Wang ZY;
展开▼
作者单位

Department of Plant Biology, Carnegie Institution of Washington, Stanford, CA 94305;

Department of Biological Sciences, Stanford University, Stanford, CA 94305;

and Department of Molecular, Cellular, and Developmental Biology, University of Michigan,;

hysiology.rwth-aachen.de;

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Phosphotransferases; Proteins; degradation; multicatalytic endopeptidase complex; 磷酸转移酶类; 蛋白质类; 拟南芥属;

相似文献

外文文献
中文文献

1. GSK3-like kinase BIN2 phosphorylates RD26 to potentiate drought signaling in Arabidopsis [J] . Hao Jiang, Buyun Tang, Zhouli XieTrevor NolanHuaxun YeGao-Yuan SongJustin WalleyYanhai Yin The Plant Journal . 2019,第5期

机译：GSK3-like kinase BIN2 phosphorylates RD26 to potentiate drought signaling in Arabidopsis
2. GSK3-like kinases positively modulate abscisic acid signaling through phosphorylating subgroup III SnRK2s in Arabidopsis [J] . Zhenying Cai, Jingjing Liu, Haijiao WangCangjing YangYuxiao ChenYongchi LiShanjin PanRui DongGuiliang TangJuan de Dios Barajas-LopezHiroaki FujiiXuelu Wang Proceedings of the National Academy of Sciences of the United States of America . 2014,第26期

机译：GSK3-like kinases positively modulate abscisic acid signaling through phosphorylating subgroup III SnRK2s in Arabidopsis
3. Histone deacetylase HDA6 enhances brassinosteroid signaling by inhibiting the BIN2 kinase [J] . Hao Yuhan, Wang Haijiao, Qiao ShenglongLeng LinnaWang Xuelu Proceedings of the National Academy of Sciences of the United States of America. . 2016,第37期

机译：Histone deacetylase HDA6 enhances brassinosteroid signaling by inhibiting the BIN2 kinase
4. BRASSINOSTEROID-SIGNALING KINASE 3 a plasma membrane-associated scaffold protein involved in early brassinosteroid signaling [O] . Hong Ren, Björn C. Willige, Yvon Jaillais, 2019

机译：BRASSINOSTEROID-SIGNALING KINASE 3与早期油菜素类固醇信号传导有关的质膜相关支架蛋白
5. Cell Entry of Avian Reovirus Follows a Caveolin-1-mediated and Dynamin-2-dependent Endocytic Pathway That Requires Activation of p38 Mitogen-activated Protein Kinase (MAPK) and Src Signaling Pathways as Well as Microtubules and Small GTPase Rab5 Protein [O] . Wei, R.Huang, Ying, C.Wang, Pei, I.Chi, 2014

机译：Cell Entry of avian Reovirus Follows a Caveolin-1-mediated and Dynamin-2-dependent Endocytic pathway That Requires activation of p38 mitogen-activated protein Kinase (mapK) and src signaling pathways as Well as microtubules and small GTpase Rab5 protein

The GSK3-like kinase BIN2 phosphorylates and destabilizes BZR1, a positive regulator of the brassinosteroid signaling pathway in Arabidopsis.

摘要

著录项

相似文献

相关主题

期刊订阅