In Vitro Antioxidant Properties, DNA Damage Protective Activity, and Xanthine Oxidase Inhibitory Effect of Cajaninstilbene Acid, a Stilbene Compound Derived from Pigeon Pea Cajanus cajan (L.) Millsp. Leaves

Nan Wu; Yu Kong; Yujie Fu

首页> 外文期刊>Journal of Agricultural and Food Chemistry >In Vitro Antioxidant Properties, DNA Damage Protective Activity, and Xanthine Oxidase Inhibitory Effect of Cajaninstilbene Acid, a Stilbene Compound Derived from Pigeon Pea Cajanus cajan (L.) Millsp. Leaves

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In Vitro Antioxidant Properties, DNA Damage Protective Activity, and Xanthine Oxidase Inhibitory Effect of Cajaninstilbene Acid, a Stilbene Compound Derived from Pigeon Pea Cajanus cajan (L.) Millsp. Leaves

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The antioxidant properties, DNA damage protective activities, and xanthine oxidase (XOD) inhibitory effect of cajaninstilbene acid (CSA) derived from pigeon pea leaves were studied in the present work. Compared with resveratrol, CSA showed stronger antioxidant properties, DNA damage protective activity, and XOD inhibition activity. The IC_(50) values of CSA for superoxide radical scavenging, hydroxyl radical scavenging, nitric oxide scavenging, reducing power, lipid peroxidation, and XOD inhibition were 19.03, 6.36, 39.65, 20.41, 20.58, and 3.62 μM, respectively. CSA possessed good protective activity from oxidative DNA damage. Furthermore, molecular docking indicated that CSA was more potent than resveratrol or allopurinol to interact with the active site of XOD (calculated free binding energy: -229.71 kcal mol~(-1)). On the basis of the results, we conclude that CSA represents a valuable natural antioxidant source and may potentially be applicable in health food industry.

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《Journal of Agricultural and Food Chemistry》 |2011年第1期|437-443|共7页
作者
Nan Wu; Yu Kong; Yujie Fu;
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作者单位

Key Laboratory of Forest Plant Ecology, and Engineering Research Center of Forest Bio-Preparation,Ministry of Education, Northeast Forestry University, Harbin 150040, China;

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正文语种英语
中图分类营养卫生、食品卫生;
关键词
Cajaninstilbene acid; stilbene; antioxidant activity: xanthine oxidase; DNA damage;

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1. Contribution of osmotic adjustment to the dehydration tolerance of water‐stressed pigeon pea (Cajanus cajan(L.) millsp.) leaves [J] . D. J. FLOWER, M. M. LUDLOW Plant, Cell & Environment . 1986,第1期

机译：Contribution of osmotic adjustment to the dehydration tolerance of water‐stressed pigeon pea (Cajanus cajan(L.) millsp.) leaves
2. In vitro callus induction and regeneration of multiple shoots through callus derived from leaf and epicotyl explants in pigeon pea (Cajanus cajan L.) [J] . Padmavathi, A.V. Thangella, B. Fakrudin Legume research . 2017,第5期

机译：In vitro callus induction and regeneration of multiple shoots through callus derived from leaf and epicotyl explants in pigeon pea (Cajanus cajan L.)
3. In vitro callus induction and regeneration of multiple shoots through callus derived from leaf and epicotyl explants in pigeon pea (Cajanus cajan L.) [J] . Padmavathi, A.V. Thangella, B. Fakrudin Legume research . 2017,第5期

机译：In vitro callus induction and regeneration of multiple shoots through callus derived from leaf and epicotyl explants in pigeon pea (Cajanus cajan L.)

In Vitro Antioxidant Properties, DNA Damage Protective Activity, and Xanthine Oxidase Inhibitory Effect of Cajaninstilbene Acid, a Stilbene Compound Derived from Pigeon Pea Cajanus cajan (L.) Millsp. Leaves

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