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Obesogens, the Exposome, and EST

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Can chemicals to which we are exposed, even in the womb, make us fat? That is the hypothesis of Bruce Blumberg, University of California at Irvine, who first coined the term "obesogen". Blumberg and colleagues published several recent papers in endocrinology journals documenting the effects of tributyltin on fetal development, which predispose stem cells to become fat cells. Other researchers report the alteration of adipose tissue development, food intake, and lipid metabolism —dramatic effects potentially caused by organotins, perfluor-ooctanoic acid (PFOA), diisobutyl phthalate, bisphenol A (BPA), and other xenobiotic chemicals found in the environment.

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