Agonizing over agonism: Should asthmatics turn their beta-receptors on or off?

Penn RB

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Agonizing over agonism: Should asthmatics turn their beta-receptors on or off?

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Since the development of albuterol 4 decades ago (1), agonists selective for the 2-adrenergic receptor(2AR) have been the drug of choice for relief of life-threatening bronchospasm experienced by asthmatics.Both short- and long-acting 2AR agonists (SABAs and LABAs,respectively) have also been used extensively for the prophylactic management of asthma symptoms. The therapeutic efficacy of 2AR agonists relates to their ability to directly relax airway smooth muscle to cause airways to dilate and conduct greater airflow.

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《Proceedings of the National Academy of Sciences of the United States of America.》 |2009年第7期|2095-2096|共2页
作者
Penn RB;
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作者单位

Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA.;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
BLOCKADE; MODEL;

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Agonizing over agonism: Should asthmatics turn their beta-receptors on or off?

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