Large eddy simulations of airflow and particle deposition in pulsating bi-directional nasal drug delivery

Ali Farnoud; Hesam Tofighian; Ingo BaumannGuilherme J. M. GarciaOtmar SchmidEva GutheilMohammad Mehdi Rashidi

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Large eddy simulations of airflow and particle deposition in pulsating bi-directional nasal drug delivery

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Chronic rhinosinusitis is a common disease worldwide, and the frequently prescribed nasal sprays do not sufficiently deliver the topical medications to the target sites so that the final treatment in severe cases is surgery. Therefore, there is a huge demand to improve drug delivery devices that could target the maxillary sinuses more effectively. In the present study, different particle diameters and device pulsation flow rates, mainly used in pulsating aerosol delivery devices such as the PARI SINUS~?, are considered to evaluate optimal maxillary sinus deposition efficiency (DE). Numerical simulations of the particle-laden flow using a large eddy simulation with a local dynamic k-equation sub-grid scale model are performed in a patient-specific nasal cavity. By increasing the pulsation flow rate from 4 l/min to 15 l/min, nasal DE increases from 37 to 68. Similarly, by increasing the particle size from 1 μm to 5 μm, nasal DE increases from 34 to 43 for a pulsation flow rate of 4 l/min. Moreover, normalized velocity, vorticities, and particle deposition pattern in different regions of the main nasal cavity and maxillary sinuses are visualized and quantified. Due to the nosepiece placement in the right nostril, more particles penetrate into the right maxillary sinus than into the left maxillary sinus despite the maxillary ostium being larger in the left cavity. Lower pulsation flow rates such as 4 l/min improve the DE in the left maxillary sinus. The use of 3 μm particles enhances the DE in the right maxillary sinus as well as the overall total maxillary drug delivery.

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《Physics of fluids》 |2020年第1期|101905-1-101905-15|共15页
作者
Ali Farnoud; Hesam Tofighian; Ingo BaumannGuilherme J. M. GarciaOtmar SchmidEva GutheilMohammad Mehdi Rashidi;
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作者单位

Comprehensive Pneumology Center, Member of the German Center for Lung Research, Max-Lebsche-Platz 31, 81377 Munich, Germany;

Mechanical Engineering Department, Amirkabir University of Technology, Tehran, Iran;

Department of Otorhinolaryngology, Head and Neck Surgery, Medical Center of Heidelberg University, Heidelberg, GermanyDepartment of Biomedical Engineering, Marquette University & The Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USAInterdisciplinary Center for Scientific Computing, Heidelberg University, Heidelberg, GermanyShanghai Automotive Wind Tunnel Center, Tongji University, Shanghai 201804, China;

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正文语种英语
中图分类流体力学;
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Large eddy simulations; airflow and particle deposition; pulsating bi-directional nasal drug delivery;

Large eddy simulations of airflow and particle deposition in pulsating bi-directional nasal drug delivery

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