Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia

Freitag N.; Tirado-Gonza?ez I.; Barrientos G.Herse F.Thijssen V.L.J.L.Weedon-Fekj?r S.M.Schulz H.Wallukat G.Klapp B.F.Nevers T.Sharma S.Staff A.C.Dechend R.Blois S.M.

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Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia

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Preeclampsia (PE) is a pregnancy-specific disorder characterized by sudden onset of hypertension and proteinuria in the second half of pregnancy (>20 wk). PE is strongly associated with abnormal placentation and an excessive maternal inflammatory response. Galectin-1 (Gal-1), a member of a family of carbohydrate-binding proteins, has been shown to modulate several processes associated with placentation and to promote maternal tolerance toward fetal antigens. Here, we show that Gal-1 exhibits proangiogenic functions during early stages of pregnancy, promoting decidual vascular expansion through VEGF receptor 2 signaling. Blocking Gal-1-mediated angiogenesis or lectin, galactoside-binding, soluble, 1 deficiency results in a spontaneous PE-like syndrome in mice, mainly by deregulating processes associated with good placentation and maternal spiral artery remodeling. Consistent with these findings, we observed a down-regulation of Gal-1 in patients suffering from early onset PE. Collectively, these results strengthen the notion that Gal-1 is required for healthy gestation and highlight Gal-1 as a valuable biomarker for early PE diagnosis.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2013年第28期|11451-11456|共6页
作者
Freitag N.; Tirado-Gonza?ez I.; Barrientos G.Herse F.Thijssen V.L.J.L.Weedon-Fekj?r S.M.Schulz H.Wallukat G.Klapp B.F.Nevers T.Sharma S.Staff A.C.Dechend R.Blois S.M.;
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作者单位

Department of Obstetrics and Gynecology, Oslo University Hospital, Ullev?l, University of Oslo, 0450, Oslo, Norway;

Experimental and Clinical Research Center, Max-Delbrück Center for Molecular Medicine, HELIOS Klinikum Berlin-Buch, 13125 Berlin, Germany;

Charité Center 12 Internal Medicine and Dermatology, Reproductive Medicine Research Group, Universit?tsmedizin Berlin, 13353 Berlin, GermanyDepartments of Radiation Oncology and Medical Oncology, Angiogenesis Laboratory, Vrije Universiteit University Medical Center, 1081 HV, Amsterdam, NetherlandsMax-Delbrück Center for Molecular Medicine, 13092 Berlin, GermanyDepartment of Pediatrics, Women and Infants Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02912, United States;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Gal-1-mediated angiogenesis contributes; pathogenesis; preeclampsia;

Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia

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