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首页> 外文期刊>Medicine and science in sports and exercise >Aerobic training effects on glucose tolerance in prediabetic and normoglycemic humans
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Aerobic training effects on glucose tolerance in prediabetic and normoglycemic humans

机译：有氧训练对糖尿病前和血糖正常人葡萄糖耐量的影响

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Introduction: It is generally accepted that if prediabetic individuals adopt healthy lifestyle habits, the progression to type 2 diabetes mellitus can be prevented or delayed. However, the role of exercise training independent of other lifestyle factors has not been determined. Furthermore, patients with type 2 diabetes mellitus have been shown to experience greater training-induced changes in glucose and insulin metabolism compared with healthy subjects, but the adaptations of prediabetic individuals have not been adequately examined. We hypothesized that (i) prediabetic subjects would have greater endurance training-induced changes in plasma glucose and insulin responses to an oral glucose challenge compared with age-and body mass index-matched normoglycemic subjects and (ii) training would completely reverse the abnormal glucose metabolism of prediabetic subjects. Methods: Plasma glucose and insulin responses to oral glucose tolerance tests (OGTTs) were examined in normoglycemic (n = 119) and prediabetic (n = 47) older men and women before and after a 6-month standardized endurance exercise training program. RESULTS: Prediabetic subjects had greater glucose and insulin OGTT responses than normoglycemic subjects both before and after training (P < 0.05). Prediabetic subjects had greater training-induced changes in glucose and insulin areas under the glucose tolerance curve, as well as greater changes in glucose and insulin concentrations at several points of the OGTT. However, these changes did not eliminate the baseline differences in glucose tolerance between normoglycemic and prediabetic subjects. The between-group differences in changes in glucose and insulin variables were largely independent of changes in body weight or composition. Conclusions: Our data indicate that prediabetes is associated with greater training-induced changes in glucose tolerance. However, 6 months of endurance training alone was not sufficient to completely reverse prediabetes.
机译：简介：一般认为，如果糖尿病前期个体养成健康的生活方式，则可以预防或延迟向2型糖尿病的发展。但是，尚未确定独立于其他生活方式因素的运动训练的作用。此外，与健康受试者相比，已显示2型糖尿病患者经历了更大的训练诱发的葡萄糖和胰岛素代谢变化，但尚未充分检查糖尿病前个体的适应性。我们假设（i）与年龄和体重指数匹配的正常血糖受试者相比，（i）糖尿病前期受试者具有更大的耐力训练诱发的血浆葡萄糖和胰岛素对口服葡萄糖激发的反应变化，并且（ii）训练将完全逆转异常葡萄糖糖尿病前期受试者的新陈代谢。方法：在6个月的标准耐力运动训练计划前后，检查了正常血糖（n = 119）和糖尿病前（n = 47）老年男女的血浆葡萄糖和胰岛素对口服葡萄糖耐量测试（OGTT）的反应。结果：在训练前后，糖尿病前期受试者的血糖和胰岛素OGTT反应均高于正常血糖受试者（P <0.05）。糖尿病前期受试者在葡萄糖耐量曲线下的训练引起的葡萄糖和胰岛素面积变化更大，在OGTT的几个点上，葡萄糖和胰岛素浓度变化更大。但是，这些变化并没有消除正常血糖患者和糖尿病前受试者之间葡萄糖耐量的基线差异。葡萄糖和胰岛素变量变化的组间差异在很大程度上与体重或组成的变化无关。结论：我们的数据表明，糖尿病前期患者与训练引起的葡萄糖耐量变化更大有关。但是，仅进行6个月的耐力训练不足以完全逆转前驱糖尿病。

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