Reply to Schmidt et al.: The long and the short of BAG1

Manji H; McEwen BS

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Reply to Schmidt et al.: The long and the short of BAG1

【24h】

Reply to Schmidt et al.: The long and the short of BAG1

机译：

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Schmidt et al. (1) have raised an important point, and we arepleased to be able to respond and provide clarification. Theysuggest that the BAG1S form (which was overexpressed inthese mice) does not inhibit glucocorticoid receptors (GRs)and that the phenotypes that we observe in our BAG1-overexpressingmice (2) are thus not likely to be correlated to adisturbed GR and stress system. Below we cite evidence tosupport our article’s assertion. Kanelakis et al. (3) found thatoverexpressed BAG1S was able to inhibit GR function dependingon the ratio of BAG1S proteins to Hsp70/Hsc70. BecauseBAG1 was overexpressed in our mice, it may be continuouslybound to Hsp70 and thus able to block GR function(3). Furthermore, Schneikert et al. in a paper cited by theauthors (4) discuss whether BAG1 may have different effectson hormone binding by GRs due to differences in the ratio ofBAG1 proteins to Hsp70/Hsc70. Clearly, this may be the casefor BAG1-overexpressing mice. Second, BAG1S may competewith common targets for BAG1M and BAG1L, thus freeingthese isoforms to inhibit GR function. Third, BAG1S maydirectly interact with the Hsp70, Hsp90, p60/Hop, Hsp-40-GRcomplex at high concentrations and inhibit GR function.Given that BAG1’s regulation of GRs is still being elucidated,it seems unreasonable to rule out a potential role for BAG1Sin disrupting the GR and stress system. However, we appreciatethe comments by Schmidt et al. (1), which help illuminatethis issue and highlight topics for continuing research.

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2008年第49期|E102-E102|共1页
作者
Manji H; McEwen BS;
展开▼
作者单位

NIMH, Mood & Anxiety Disorders Program, Bethesda, MD 20892 USA.;

Rockefeller Univ, New York, NY 10021 USA.;

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
GLUCOCORTICOID-RECEPTOR;

相似文献

外文文献
中文文献
专利

1. Cryobiopsy Compared with Surgical Lung Biopsy in ILD: Reply to Maldonado et al., Froidure et al., Bendstrup et al., Agarwal et al., Richeldi et al., Rajchgot et al., and Quadrelli et al. [J] . Romagnoli Micaela, Colby Thomas V., Suehs Carey M.Vachier IsabelleMolinari NicolasBourdin Arnaud American journal of respiratory and critical care medicine . 2019,第7期

机译：Cryobiopsy Compared with Surgical Lung Biopsy in ILD: Reply to Maldonado et al., Froidure et al., Bendstrup et al., Agarwal et al., Richeldi et al., Rajchgot et al., and Quadrelli et al.
2. Reply to Adam G. Sowalsky, Stephen R. Plymate, Michael C. Haffner, Johann S. de Bono, and Adam Sharp's Letter to the Editor re: Heng Li, Yucong Zhang, Dong Li, et al. Androgen Receptor Splice Variant 7 Predicts Shorter Response in Patients with Metastatic Hormone-sensitive Prostate Cancer Receiving Androgen Deprivation Therapy. Eur Urol 2021;79:879–86: AR-V7 is Rare in Hormone-sensitive Prostate Cancer [J] . Li H., Zhang Y., Xu H. European urology . 2022,第5期

机译：Reply to Adam G. Sowalsky, Stephen R. Plymate, Michael C. Haffner, Johann S. de Bono, and Adam Sharp's Letter to the Editor re: Heng Li, Yucong Zhang, Dong Li, et al. Androgen Receptor Splice Variant 7 Predicts Shorter Response in Patients with Metastatic Hormone-sensitive Prostate Cancer Receiving Androgen Deprivation Therapy. Eur Urol 2021;79:879–86: AR-V7 is Rare in Hormone-sensitive Prostate Cancer
3. A comment and a reply to the paper by Kristinn Tomasson et al.: “Failed and short seizures associated with prior electroconvulsive therapy” [J] . KristinnTomasson, GeorgeWinokur, BrucePfohlRichardAbrams european archives of psychiatry and clinical neuroscience . 1992,第1期

机译：A comment and a reply to the paper by Kristinn Tomasson et al.: “Failed and short seizures associated with prior electroconvulsive therapy”
4. 1 H. Miyake et al., JCG 456, 155 (2016). 2 K. Uesugi et al., APEX 12, 065501 (2019). 3 上杉他, 第67回応用物理学会春季学術講演会 15p-A302-7 (2020). 4 K. Uesugi et al., APL 116, 062101 (2020). [C] . 藤岡洋, 上野耕平, 小林篤 . -1

机译：1 H. Miyake et al., JCG 456, 155 (2016). 2 K. Uesugi et al., APEX 12, 065501 (2019). 3 上杉他, 第67回応用物理学会春季学术讲演会15p-A302-7 (2020). 4 K. Uesugi et al., APL 116, 062101 (2020).
5. Development of three reaction methodologies en route to nitrogen containing heterocycles: A Diels-Alder/Schmidt, a Diels-Alder/acylation and a catalytic intramolecular Schmidt. [D] . Hirt, Erin E. 2009

机译：三种反应方法在含氮杂环反应中的发展：Diels-Alder / Schmidt，Diels-Alder /酰化反应和催化分子内Schmidt。
6. Geng et al. reply [O] . Xinyi Wang, Guangqiang Sun, Teng Feng, 2020

机译：gen get AL. reply
7. Geng et al. reply [O] . Xinyi Wang, Guangqiang Sun, Teng Feng, 2020

机译：gen get AL. reply
8. Recycler Short Kicker Beam Impedance [R] . Crisp, J., Fellenz, B. 2009

机译：Recycler short Kicker Beam Impedance

Reply to Schmidt et al.: The long and the short of BAG1

摘要

著录项

相似文献

相关主题

期刊订阅