B cell homeostasis and plasma cell homing controlled by Krüppel-like factor 2

Winkelmann R.; Sandrock L.; Porstner M.Roth E.Mathews M.Hobeika E.Reth M.Kahn M.L.Schuh W.J?ck H.-M.

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >B cell homeostasis and plasma cell homing controlled by Krüppel-like factor 2

【24h】

B cell homeostasis and plasma cell homing controlled by Krüppel-like factor 2

机译：

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Krüppel-like factor 2 (KLF2) controls T lymphocyte egress from lymphoid organs by regulating sphingosin-1 phosphate receptor 1 (S1Pr1). Here we show that this is not the case for B cells. Instead, KLF2 controls homeostasis of B cells in peripheral lymphatic organs and homing of plasma cells to the bone marrow, presumably by controlling the expression of β_7- integrin. In micewith a B cell-specific deletion of KLF2, S1Pr1 expression on B cells was only slightly affected. Accordingly, all splenic B cell subsets including B1 cells were present, but their numbers were increased with a clear bias for marginal zone (MZ) B cells. In contrast, fewer peyers patches harboring fewer B cells were found, and fewer B1 cells in the peritoneal cavity as well as recirculating B cells in the bone marrow were detected. Upon thymus-dependent immunization, IgG titers were diminished, and antigen-specific plasma cells were absent in the bone marrow, although numbers of antigen-specific splenic plasmablastswere normal. KLF2 plays also a role in determining the identity of follicular B cells, as KLF2-deficient follicular B cells showed calcium responses similar to those of MZ B cells and failed to down-regulate MZ B cell signature genes, such as CD21 and CXCR7.

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2011年第2期|710-715|共6页
作者
Winkelmann R.; Sandrock L.; Porstner M.Roth E.Mathews M.Hobeika E.Reth M.Kahn M.L.Schuh W.J?ck H.-M.;
展开▼
作者单位

Nikolaus-Fiebiger-Center, Department of Internal Medicine III, Friedrich-Alexander-University Erlangen-Nürnberg, D-91054 Erlangen, Germany;

Centre for Biological Signalling Studies (BIOSS), University of Freiburg, Department of Molecular Immunology, D-79108 Freiburg, Germany;

Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6069, United States;

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
B cell development; Cell trafficking; Knockout mouse; LKLF; S1P1;

B cell homeostasis and plasma cell homing controlled by Krüppel-like factor 2

摘要

著录项

相关主题

期刊订阅