IL-15 plays a major role in the persistence of Tax-specific CD8 cells in HAM/TSP patients.

Azimi N; Nagai M; Jacobson SWaldmann TA

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IL-15 plays a major role in the persistence of Tax-specific CD8 cells in HAM/TSP patients.

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IL-15 is a critical cytokine for the maintenance of memory-phenotype CD8 cells in mice. Here, we investigated the role of IL-15 in the neurological disease termed human T cell lymphotropic virus I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The high number of viral-specific CD8 cells in these patients is associated with inflammatory responses in the central nervous system. Because IL-15 is overexpressed in these patients, we asked whether IL-15 contributes to the persistence of human T cell lymphotropic virus I viral-specific CD8 cells. Using ex vivo cultures of HAM/TSP peripheral blood mononuclear cells, we demonstrated that in the majority of patients examined here blocking IL-15 action resulted in a decrease in the number of viral-specific CD8 cells. This decrease was caused by both inhibition of proliferation and induction of apoptosis in these cells. The data indicate that IL-15 plays a major role in the maintenance of viral-specific CD8 cells in HAM/TSP.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2001年第25期|14559-14564|共6页
作者
Azimi N; Nagai M; Jacobson SWaldmann TA;
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作者单位

Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1374, USA. nazli;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
CD8-Positive T-Lymphocytes; Gene Products; tax; Interleukin-15; Paraparesis; Tropical Spastic; CD8阳性T淋巴细胞; 基因产物; TAX; 白细胞介素15; 轻截瘫; 热带痉挛性;

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4. IL-15 plays a major role in the persistence of Tax-specific CD8 cells in HAM/TSP patients [O] . Nazli Azimi, Masahiro Nagai, Steven Jacobson, 2001

机译：IL-15在税收专用CD8的持久性中起主要作用 HAM / TSP患者中的细胞
5. IL-15 plays a major role in the persistence of Tax-specific CD8 cells in HAM/TSP patients [O] . Azimi, Nazli, Nagai, Masahiro, Jacobson, Steven, 2001

机译：IL-15在税收专用CD8的持久性中起主要作用 HAM / TSP患者中的细胞

IL-15 plays a major role in the persistence of Tax-specific CD8 cells in HAM/TSP patients.

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