Identification and characterization of a melanin-concentrating hormone receptor.

An S; Cutler G; Zhao JJHuang SGTian HLi WLiang LRich MBakleh ADu JChen JLDai K

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Identification and characterization of a melanin-concentrating hormone receptor.

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摘要

Melanin-concentrating hormone (MCH), a neuropeptide expressed in central and peripheral nervous systems, plays an important role in the control of feeding behaviors and energy metabolism. An orphan G protein-coupled receptor (SLC-1/GPR24) has recently been identified as a receptor for MCH (MCHR1). We report here the identification and characterization of a G protein-coupled receptor as the MCH receptor subtype 2 (MCHR2). MCHR2 has higher protein sequence homology to MCHR1 than any other G protein-coupled receptor. The expression of MCHR2 has been detected in many regions of the brain. In contrast to MCHR1, which is intronless in the coding region and is located at the chromosomal locus 22q13.3, the MCHR2 gene has multiple exons and is mapped to locus 6q21. MCHR2 is specifically activated by nanomolar concentrations of MCH, binds to MCH with high affinity, and signals through Gq protein. This discovery is important for a full understanding of MCH biology and the development of potential therapeutics for diseases involving MCH, including obesity.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2001年第13期|7576-7581|共6页
作者
An S; Cutler G; Zhao JJHuang SGTian HLi WLiang LRich MBakleh ADu JChen JLDai K;
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作者单位

Tularik, Inc., Two Corporate Drive, South San Francisco, CA 94080, USA.;

o.state.ct.us;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Brain; Hypothalamic Hormones; Melanins; Pituitary Hormones; Receptors; Pituitary Hormone; 脑; 下丘脑激素类; 黑素类; 垂体激素类; 受体; 垂体激素;

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Identification and characterization of a melanin-concentrating hormone receptor.

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