...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>experimental brain research >The effect of cochlear nerve lesion on the release of glutamate, aspartate, and GABA from cat cochlear nucleus, in vitro
【24h】

The effect of cochlear nerve lesion on the release of glutamate, aspartate, and GABA from cat cochlear nucleus, in vitro

机译：

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Pool studies of glutamate and aspartate have suggested a transmitter role for these amino acids in cochlear nerve endings. As further evidence. the K+-evoked release of glutamate, aspartate and GABA was measured in cat cochlear nucleus slices in vitro and compared to the release following a cochlear nerve lesion. Using 3Hglutamine as precursor, the K+-evoked release of glutamate and γ-aminobutyric acid (GABA) was respectively 4.1 and 7.2 times the spontaneous release. Using 14Cglutamate as a marker, the K+-evoked release of glutamate and GABA was respectively 7.1 and 2.8 times the basal release. All K+-evoked releases were Ca++-dependent. Nine days after unilateral lesion of the cochlear nerve in the cat, the glutamate release decreased by about 75 on the lesioned side compared to the intact one, whereas the GABA release was not decreased. The labelled tissue glutamate, either synthesized from 3Hglutamine or labelled with 14Cglutamate, was also markedly decreased on the lesioned side. In comparison, the evoked release of aspartate, newly synthesized from 14Cglutamate, remained low and was only decreased by about 45 after cochlear nerve lesions. Comparing cat with rat cochlear nucleus, the glutamate release was similar in both animals, whereas the GABA release was much higher in the rat

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号