Radioautographic identification of lactogen binding sites in rat median eminence using125I-human growth hormone: Evidence for a prolactin “short-loop” feedback site

Dr.M.vanHouten; B.I.Posner; R.J.Walsh

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Radioautographic identification of lactogen binding sites in rat median eminence using125I-human growth hormone: Evidence for a prolactin “short-loop” feedback site

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The binding characteristics of human growth hormone were exploited to identify radioautographically lactogen binding sites in the rat median eminence. Following systemic injection125I-human growth hormone bound preferentially to the lateral palisade zone, a region of median eminence rich in dopamine and LHRH. Coinjection of125I-human growth hormone with an excess of unlabeled human growth hormone or ovine prolactin, but not bovine growth hormone, competitively blocked125I-human growth hormone binding to the external median eminence. These observations provide direct evidence of recognition sites for lactogenic hormones in a discrete region of the median eminence associated with hypothalamic regulation of hypophyseal prolactin and luteinizing hormone secretion. Median eminence lactogen binding sites may mediate presumed direct effects of lactogenic hormones on the reproductive functions of the hypophysiotropic hypothalamus.

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《experimental brain research》 |1980年第4期|455-461|共页
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Dr.M.vanHouten; B.I.Posner; R.J.Walsh;
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McGill University;

George Washington University Medical Center;

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1. Autoradiographic Identification of Prolactin Binding Sites in Rat Median Eminence [J] . Anne C. Barton, Robert A. Lahti, Montford F. PierceyKenneth E. Moore neuroendocrinology . 1989,第6期

机译：Autoradiographic Identification of Prolactin Binding Sites in Rat Median Eminence
2. Effects of Castration and Maturational Age of Male Rats on the Process of Copper-Stimulated Release of Luteinizing Hormone Releasing Hormone from Median Eminence Explants: Evidence that Androgens Increase the Affinity of the Copper-Interactive Sites for Copper [J] . Miriam Colombani-Vidal, Ayalla Barnea neuroendocrinology . 1985,第6期

机译：Effects of Castration and Maturational Age of Male Rats on the Process of Copper-Stimulated Release of Luteinizing Hormone Releasing Hormone from Median Eminence Explants: Evidence that Androgens Increase the Affinity of the Copper-Interactive Sites for Copper
3. Localization of the site of the haloperidol-induced, prolactin-mediated increase of dopamine turnover in the median eminence: Studies in rats with complete hypothalamic deafferentations [J] . G.A.Gudelsky, L.Annunziato, K.E.Moore journal of neural transmission . 1978,第3期

机译：Localization of the site of the haloperidol-induced, prolactin-mediated increase of dopamine turnover in the median eminence: Studies in rats with complete hypothalamic deafferentations

Radioautographic identification of lactogen binding sites in rat median eminence using125I-human growth hormone: Evidence for a prolactin “short-loop” feedback site

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