CRISPR/Cas9 in the era of nanomedicine and synthetic biology

Schmidt T.J.N.; Berarducci B.; Konstantinidou S.Raffa V.

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CRISPR/Cas9 in the era of nanomedicine and synthetic biology

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? 2022 The AuthorsThe CRISPR/Cas system was first discovered as a defense mechanism in bacteria and is now used as a tool for precise gene-editing applications. Rapidly evolving, it is increasingly applied in therapeutics. However, concerns about safety, specificity, and delivery still limit its potential. In this context, we introduce the concept of nanogenetics and speculate how the rational engineering of the CRISPR/Cas machinery could advance the biomedical field. In nanogenetics, the advantages of traditional approaches of synthetic biology could be expanded by nanotechnology approaches, enabling the design of a new generation of intrinsically safe and specific genome-editing platforms.

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《Drug discovery today》 |2023年第1期|103375-103375|共7页
作者
Schmidt T.J.N.; Berarducci B.; Konstantinidou S.Raffa V.;
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作者单位

Department of Biology University of Pisa;

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原文格式 PDF
正文语种英语
中图分类药学;
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Genome editing; Nanogenetics; Nanomedicine; Synthetic biology;

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CRISPR/Cas9 in the era of nanomedicine and synthetic biology

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