Rapid analysis of local data to inform off-label tocilizumab use early in the COVID-19 pandemic

Morgan Camille E.; Rimland Casey A.; Bell Griffin J.Kim Min K.Hedrick TannerMarx AshleyBramson BrianSwygard HeidiNapravnik SoniaSchmitz John L.Carson Shannon S.Fischer William A.Eron Joseph J.Gay Cynthia L.Parr Jonathan B.

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Rapid analysis of local data to inform off-label tocilizumab use early in the COVID-19 pandemic

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The interleukin-6 receptor antagonist tocilizumab became widely used early in the coronavirus disease 2019 (COVID-19) pandemic based on small observational studies that suggested clinical benefit in COVID-19 patients with a hyperinflammatory state. To inform our local treatment algorithms in the absence of randomized clinical trial results, we performed a rapid analysis of the first 11 hospitalized COVID-19 patients treated with tocilizumab at our academic medical center. We report their early clinical outcomes and describe the process by which we assembled a team of diverse trainees and stakeholders to extract, analyze, and disseminate data during a time of clinical uncertainty.

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《Healthcare.》 |2021年第4期|100581-100581|共7页
作者
Morgan Camille E.; Rimland Casey A.; Bell Griffin J.Kim Min K.Hedrick TannerMarx AshleyBramson BrianSwygard HeidiNapravnik SoniaSchmitz John L.Carson Shannon S.Fischer William A.Eron Joseph J.Gay Cynthia L.Parr Jonathan B.;
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UNC Sch Med;

UNC Gillings Sch Global Publ Hlth;

UNC Med CtrUNC Sch MedUNC Sch Med;

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原文格式 PDF
正文语种英语
中图分类保健组织与事业（卫生事业管理）;
关键词
SARS-CoV-2; Evidence-based decision-making; Tocilizumab; Cytokine release syndrome; COVID-19; Interleukin 6 (IL-6);

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Rapid analysis of local data to inform off-label tocilizumab use early in the COVID-19 pandemic

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