...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of pharmacokinetics and biopharmaceutics >Estimation of area under the curve for drugs subject to enterohepatic cycling
【24h】

Estimation of area under the curve for drugs subject to enterohepatic cycling

机译：

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A physiologically realistic model is used to provide insight into the design of sampling protocols for accurate determination ofAUC(0– ∞) for drugs subject to enterohepatic cycling. Through simulation of plasma concentration- time curves for such drugs it is found that (1) more than one peak is predicted after oral and intravenous administration of a single dose of drug, (2) the relative magnitude of peaks is dependent on the hepatic extraction ratio for both oral and intravenous drug administration, (3) the percent of theAUC(0– ∞) in later time intervals is also a function of the hepatic extraction ratio, and (4) present methods for the design of sampling protocols may not provide accurate estimates ofAUC(0– ∞) (especially for highly extracted drugs), because (a) peaks are only evident at later times after intravenous administration when plasma sampling is less frequent, (b) much of the area occurs at later times, and (c) the amount of drug in the sampling compartment after oral administration is much lower than that after intravenous administration of drug and could be incorrectly interpreted as low bioavailability if sampling is not carried out for a long period of time. The types of oral and intravenous profiles predicted for highly extracted drugs are exemplified by data for naltrexone in

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号