Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo.

Miller BC; Eckman EA; Sambamurti KDobbs NChow KMEckman CBHersh LBThiele DL

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo.

【24h】

Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo.

机译：

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Factors that elevate amyloid-beta (Abeta) peptide levels are associated with an increased risk for Alzheimer's disease. Insulysin has been identified as one of several proteases potentially involved in Abeta degradation based on its hydrolysis of Abeta peptides in vitro. In this study, in vivo levels of brain Abeta40 and Abeta42 peptides were found to be increased significantly (1.6- and 1.4-fold, respectively) in an insulysin-deficient gene-trap mouse model. A 6-fold increase in the level of the gamma-secretase-generated C-terminal fragment of the Abeta precursor protein in the insulysin-deficient mouse also was found. In mice heterozygous for the insulysin gene trap, in which insulysin activity levels were decreased approximately 50, brain Abeta peptides were increased to levels intermediate between those in wild-type mice and homozygous insulysin gene-trap mice that had no detectable insulysin activity. These findings indicate that there is an inverse correlation between in vivo insulysin activity levels and brain Abeta peptide levels and suggest that modulation of insulysin activity may alter the risk for Alzheimer's disease.

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2003年第10期|6221-6226|共6页
作者
Miller BC; Eckman EA; Sambamurti KDobbs NChow KMEckman CBHersh LBThiele DL;
展开▼
作者单位

Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas 75390-9151, USA. bonnie.miller@utsouthwestern.edu;

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类基础医学;
关键词
Amyloid beta-Protein; Brain; Insulysin; 淀粉样β蛋白; 脑; 胰岛素溶酶;

相似文献

外文文献
中文文献

1. Natural Killer Susceptibility of Brain Tumor Cell Lines Inversely Correlates with the Degree of Cell Differentiation and Not with the Level of Human Histocompatibility Antigen Expression [J] . Corona Alonso, Rafael Serrano, Rafael SolanaJosé Peña international archives of allergy and immunology . 1989,第3期

机译：Natural Killer Susceptibility of Brain Tumor Cell Lines Inversely Correlates with the Degree of Cell Differentiation and Not with the Level of Human Histocompatibility Antigen Expression
2. Elevated levels of sCD48 are inversely correlated with markers of disease activity in bullous pemphigoid [J] . Emma Treco, Eunice Huan, Afshin VarzavandJanet A. FairleyKelly?N. Messingham Experimental dermatology. . 2023,第1期

机译：Elevated levels of sCD48 are inversely correlated with markers of disease activity in bullous pemphigoid
3. Inhibitory activity of the human papillomavirus type 1 AU-rich element correlates inversely with the levels of the elav-like HuR protein in the cell cytoplasm. [J] . Carlsson A, Schwartz S Archives of virology . 2000,第3期

机译：Inhibitory activity of the human papillomavirus type 1 AU-rich element correlates inversely with the levels of the elav-like HuR protein in the cell cytoplasm.
4. Effect of dietary carbohydrate levels on growth performance, body composition, intestinal and hepatic enzyme activities, and growth hormone gene expression of juvenile golden pompano, Trachinotus ovatus [O] . Zhou Chuanpeng, Ge Xianping, Niu Jin, 2015

机译：Effect of dietary carbohydrate levels on growth performance, body composition, intestinal and hepatic enzyme activities, and growth hormone gene expression of juvenile golden pompano, Trachinotus ovatus

Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo.

摘要

著录项

相似文献

相关主题

期刊订阅