Senotherapeutics for mesenchymal stem cell senescence and rejuvenation

Wong P.-F.; Dharmani M.; Ramasamy T.S.

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Senotherapeutics for mesenchymal stem cell senescence and rejuvenation

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? 2022 Elsevier LtdMesenchymal stem cells (MSCs) are susceptible to replicative senescence and senescence-associated functional decline, which hampers their use in regenerative medicine. Senotherapeutics are drugs that target cellular senescence through senolytic and senomorphic functions to induce apoptosis and suppress chronic inflammation caused by the senescence-associated secreted phenotype (SASP), respectively. Therefore, senotherapeutics could delay aging-associated degeneration. They could also be used to eliminate senescent MSCs during in vitro expansion or bioprocessing for transplantation. In this review, we discuss the role of senotherapeutics in MSC senescence, rejuvenation, and transplantation, with examples of some tested compounds in vitro. The prospects, challenges, and the way forward in clinical applications of senotherapeutics in cell-based therapeutics are also discussed.

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《Drug discovery today》 |2023年第1期|103424-103424|共8页
作者
Wong P.-F.; Dharmani M.; Ramasamy T.S.;
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作者单位

Department of Pharmacology Faculty of Medicine Universiti Malaya;

Stem Cell Biology Laboratory Department of Molecular Medicine Faculty of Medicine Universiti Malaya;

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原文格式 PDF
正文语种英语
中图分类药学;
关键词
cellular senescence; rejuvenation; senolytics; senomorphics; stem cell therapy;

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Senotherapeutics for mesenchymal stem cell senescence and rejuvenation

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