Ikaros promotes early-born neuronal fates in the cerebral cortex

Jessica M. Alsi?; Basile Tarchini; Michel CayouetteFrederick J. Livesey

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Ikaros promotes early-born neuronal fates in the cerebral cortex

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The mammalian nervous system contains an extraordinary number of different cell types that are produced from a pool of neural progenitor cells during development. For proper brain function, it is essential that all the different cell identities be accurately specified. This specification occurs in four dimensions, relying not only on regional patterning of the brain into its distinct areas but also on a succession of changes within the progenitor cells over time known as temporal patterning. Along the temporal axis, individual progenitor cells transit through different competence states, phases during which they are able to generate a narrow, specific range of neurons. As a result, distinct sets of neurons are produced in a fixed chronological order. Despite the recent identification of large numbers of genes involved in differentiation of specific subclasses of neurons, not much is known about how the timing of production of different neurons is regulated at the progenitor cell level. In this study, we identify a role for a family of transcription factors in controlling the ability of progenitor cells of the cerebral cortex to generate early neuronal identities, a role that is conserved among different brain regions and different species.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2013年第8期|2710-2711|共2页
作者
Jessica M. Alsi?; Basile Tarchini; Michel CayouetteFrederick J. Livesey;
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作者单位

Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QN, United Kingdom;

Cellular Neurobiology Research Unit, Institut de Recherches Cliniques de Montréal, Montreal, QC, Canada H2W 1R7;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
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1. Ikaros promotes early-born neuronal fates in the cerebral cortex (vol 110, pg E716, 2013) [J] . Alsioe Jessica M., Tarchini Basile, Cayouette MichelLivesey Frederick J. Proceedings of the National Academy of Sciences of the United States of America . 2015,第23期

机译：Ikaros promotes early-born neuronal fates in the cerebral cortex (vol 110, pg E716, 2013)
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Ikaros promotes early-born neuronal fates in the cerebral cortex

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