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首页> 外文期刊>Clinics and research in hepatology and gastroenterology. >Detection of occult hepatitis B virus infection among subjects with isolated hepatitis B core antibodies: Results from a 3-year survey in an Italian tertiary-care hospital
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Detection of occult hepatitis B virus infection among subjects with isolated hepatitis B core antibodies: Results from a 3-year survey in an Italian tertiary-care hospital

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? 2022 Elsevier Masson SASBackground: Hepatitis B virus (HBV) infection causes hepatitis, liver cirrhosis, hepatocellular carcinoma, and death. This study examines the subjects with isolated anti-HBV core antigen antibody (anti-HBcAg), a pattern characterized by the persistent HBV carriage in the absence of HBV surface antigen (HBsAg) and anti-HBsAg antibody. Methods: Based on medical orders, from 2017 to 2019, serological and molecular assays were performed on serum/plasma samples of 33,048 subjects (71.4 Italians, 28.6 foreigners), who referred to the Virology Unit of the University-Hospital of Parma (Northern Italy) for the laboratory diagnosis of HBV infection. Results: The seroprevalence was 4.6 for HBsAg and 11 for anti-HBcAg. The occurrence of the isolated anti-HBcAg status was 3.1, with higher frequency in males than in females (66.3 vs. 33.7, P < 0.0001), in Italians than in foreigners (54.8 vs. 45.2, P < 0.001), and in outpatients than in inpatients (57.4 vs. 42.6, P < 0.0001). Foreigners with isolated anti-HBcAg came mostly from Africa (67.9) and Eastern Europe (26.2). Among subjects with isolated anti-HBcAg, 14.8 had occult HBV infection, 26.3 hepatitis C virus co-infection, 2 human immunodeficiency virus co-infection, and 3.3 both of these latter co-infections. Conclusions: The anti-HBcAg assay accurately evaluates the HBV exposure; subjects with isolated anti-HBcAg antibody should be further analysed for HBV DNA. The HBV infection prevalence in Italy is increasing, due to growing migratory flows from endemic areas.

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