Abortive base-excision repair of radiation-induced clustered DNA lesions in Escherichia coli.

Blaisdell JO; Wallace SS

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Abortive base-excision repair of radiation-induced clustered DNA lesions in Escherichia coli.

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It has been postulated that ionizing radiation produces a unique form of cellular DNA damage called "clustered damages" or "multiply damaged sites". Here, we show that clustered DNA damages are indeed formed in Escherichia coli by ionizing radiation and are converted to lethal double-strand breaks during attempted base-excision repair. In wild-type cells possessing the oxidative DNA glycosylases that cleave DNA at repairable single damages, double-strand breaks are formed at radiation-induced clusters during postirradiation incubation and also in a dose-dependent fashion. E. coli mutants lacking these enzymes do not form double-strand breaks postirradiation and are substantially more radioresistant than wild-type cells. Furthermore, overproduction of one of the oxidative DNA glycosylases in mutant cells confers a radiosensitive phenotype and an increase in the number of double-strand breaks. Thus, the effect of the oxidative DNA glycosylases in potentiating DNA damage must be considered when estimating radiation risk.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2001年第13期|7426-7430|共5页
作者
Blaisdell JO; Wallace SS;
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作者单位

Department of Microbiology and Molecular Genetics, Markey Center for Molecular Genetics, University of Vermont, Stafford Hall, Burlington, VT 05405-0068, USA.;

o.state.ct.us;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Base Pair Mismatch; DNA Damage; DNA Repair; DNA; Bacterial; Escherichia coli; 碱基错配; DNA损伤; DNA修复; 细菌; 大肠杆菌;

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Abortive base-excision repair of radiation-induced clustered DNA lesions in Escherichia coli.

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